Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α

Research Project

Project/Area Number	22700661
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Sports science
Research Institution	Kyoritsu Women's Junior College (2011) Nippon Medical School (2010)
Principal Investigator	NAKAJIMA Sanae 共立女子短期大学, 文科, 講師 (60535459)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	運動 / 神経新生 / 海馬 / ストレス / 血管新生 / VEGF
Research Abstract	The purpose of this study was to investigate whether exercise-induced enhancement of hippocampal neurogenesis and prevention of depression is attributed to VEGF signaling pathway of hippocampus dependently on hepatic VEGF. The preset findings suggested that regular exercise prevents stress-induced onset of depression via VEGF signaling pathway of hippocampus independently of exercise-induced increase of hepatic VEGF.