| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We focused on relationship between muscle contractile activity and autophagy induction in atrophying muscle during fasting. To examine the effect of contraction activity, compensatory muscle overload(increase of muscle contraction) and denervation(decrease of muscle contraction) models were used in this study. This study showed that fasting-related muscle atrophy level was decreased in compensatory overloading group, while the level was increased in denervation group. It was suggested that autophagy induction partially contributes the mitigation of muscle atrophy by contractile activity during fasting.
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