Effect of Skeletal Muscle-Drived Growth-Arrest Specific gene 6 on Phenotype Switching of Macrophages in Injured-Muscle in mice
| Project/Area Number |
22700704
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Kurashiki University of Science and the Arts |
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Principal Investigator |
SHIVA Daisuke 倉敷芸術科学大学, 生命科学部, 講師 (20515233)
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| Co-Investigator(Renkei-kenkyūsha) |
YANO Hiromi 川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
SUZUKI Katsuhiko 早稲田大学, スポーツ科学学術院, 准教授 (80344597)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Gas6 / マクロファージ / 骨格筋 / M1/M2 / siRNA / 貪食 / C2C12 / M1 / M2 / スイッチング / 食喰 |
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| Research Abstract |
This study examined that the Gas6 expression and regulation of macrophages functions by Gas6 in injured-skeletal muscle. In the results, it observed that injured-skeletal muscle by Cardiotoxin-induction was increased Gas6 expression compared with control muscle. In addition, it observed that Gas6 stimulation regulate macrophages phenotype.
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Report
(4 results)
Research Products
(16 results)
