The effect of ghrelin genotype on exercise behavior.

• Project/Area Number: 22700708
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: National Institute of Health and Nutrition
• Principal Investigator: MURAKAMI Haruka 独立行政法人国立健康・栄養研究所, 健康増進研究部, 特別研究員 (20344880)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: スポーツ医学 / 身体活動・運動行動 / 摂食行動 / グレリン遺伝子多型 / 自発的身体活動量 / メラノコルチン4受容体遺伝子多型 / レプチン受容体遺伝子多型

Research Abstract

The purpose of this study was to evaluate the effects of polymorphisms of eating behavior-related gene on physical activity(PA) level. Daily PA was measured by triaxial accelerometry. There was a significant difference of moderate to vigorous physical activity among genotype of leptin receptor gene. Also there was a significant relation between the change of physical activity level by intervention and its genotype. It has been suggested that leptin receptor gene might relate to daily physical activity level.

Research Products

• [Journal Article] 健康づくりのための運動基準2006における身体活動量の基準値週23メッツ・時と1日あたりの歩数との関連 (2012)
  • Author(s): 村上晴香,川上諒子,大森由実,宮武伸行,森田明美,宮地元彦
  • Journal Title: 体力科学 Volume: 61 Pages: 183-191
  • NAID: 10030140362
  • URL: https://www.jstage.jst.go.jp/article/jspfsm/61/2/61_2_183/_pdf
  • Peer Reviewed
• [Journal Article] Association of 29C T Polymorphism in the Transforming Growth Factor-β1 Gene with Lean Body Mass in Community-Dwelling Japanese Population (2012)
  • Author(s): Fuku N, Mori S, Murakami H, Gando Y, Zhou H, Ito H, Tanaka M, Miyachi M
  • Journal Title: Geriatr Gerontol Int Volume: 12 Issue: 2 Pages: 292-297
  • DOI: 10.1111/j.1447-0594.2011.00768.x
  • NAID: 10031147995
  • Peer Reviewed
• [Journal Article] 運動能力を引き出す遺伝と多様性の科学(7)身体活動・運動行動に関連する遺伝子多型から運動能力を考える (2011)
  • Author(s): 村上晴香
  • Journal Title: 体育の科学 Volume: 61 Pages: 777-783
  • NAID: 40019020739
• [Journal Article] 運動能力を引き出す遺伝と多様性の科学(3)運動能力(筋力・筋パワーおよび持久的能力)と遺伝率 (2011)
  • Author(s): 村上晴香
  • Journal Title: 体育の科学 Volume: 61 Pages: 441-445
  • NAID: 40018815885
• [Journal Article] Age differences in the relation between ACTN3 R577X polymorphism and thigh-muscle cross-sectional area in women (2011)
  • Author(s): Zempo H, Tanabe K, Murakami H, Iemitsu M, Maeda S, Kuno S.
  • Journal Title: Genet Test Mol Biomarkers Volume: 15 Issue: 9 Pages: 639-643
  • DOI: 10.1089/gtmb.2011.0005
  • NAID: 120007137466
  • Peer Reviewed
• [Journal Article] Associations among objectively measured physical activity,fasting plasma homocysteine concentration, and MTHFR C677T genotype. (2011)
  • Author(s): Murakami H, M Iemitsu, K Sanada, Y Gando, Y Ohmori, R Kawakami, S Sasaki, I Tabata, M Miyachi.
  • Journal Title: Eur J Appl Physiol Volume: 111(12) Issue: 12 Pages: 2997-3005
  • DOI: 10.1007/s00421-011-1926-z
  • Peer Reviewed
• [Journal Article] PPAR γ 2 C1431T genotype increases metabolic syndrome risk in young men with owcardiorespiratory fitness (2011)
  • Author(s): Sanada K, M Iemitsu, H Murakami, I Tabata, K Yamamoto, Y Gand, K Suzuki, M Higuchi, M Miyachi.
  • Journal Title: PhysiolGenomics Volume: 43 Issue: 3 Pages: 103-109
  • DOI: 10.1152/physiolgenomics.00129.2010
  • Peer Reviewed
• [Journal Article] Attenuated Age-Related Carotid Arterial Remodeling in Adults with a High Level of Cardiorespiratory Fitness (2011)
  • Author(s): Gando Y, Yamamoto K, Kawano H, Murakami H, Ohmori Y, Kawakami R, Sanada K, Higuchi M, Tabata I, Miyachi M.
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 248-254
  • NAID: 130004444505
  • URL: http://dx.doi.org/10.5551/jat.6924
  • Peer Reviewed
• [Journal Article] Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype. (2011)
  • Author(s): Murakami H., et al.
  • Journal Title: Eur J Appl Physiol. Volume: (online)
  • Peer Reviewed
• [Journal Article] Longer time spent in light physical activity is associated with reduced arterial stiffness in older adults (2010)
  • Author(s): Gando Y, Yamamoto K, Murakami H, Ohmori Y, Kawakami R, Sanada K, Higuchi M, Tabata I, Miyachi M.
  • Journal Title: Hypertension Volume: 56 Issue: 3 Pages: 540-546
  • DOI: 10.1161/hypertensionaha.110.156331
  • Peer Reviewed
• [Journal Article] PPAR{gamma}2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness. (2010)
  • Author(s): Sanada K., et al.
  • Journal Title: Physiol Genomics. Volume: 43 Pages: 103-109
  • Peer Reviewed
• [Presentation] グレリンおよびレプチンレセプターの遺伝子多型と身体活動・運動行動との関連 (2011)
  • Author(s): 村上晴香,家光素行,真田樹義,福典之,丸藤祐子,川上諒子,宮地元彦
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 山口
  • Year and Date: 2011-09-17
• [Presentation] 運動・身体活動の効果の個人差を遺伝子多型から考える (2011)
  • Author(s): 村上晴香
  • Organizer: 第19回日本運動生理学会
  • Place of Presentation: 徳島
  • Year and Date: 2011-08-26
• [Presentation] Genome-Wide Association Study of Physical Activity Level for a Year in Japanese Adults (2011)
  • Author(s): Murakami H, Iemitsu M, Sanada K, Gando Y, Kawakami R, Fuku N, Hayashi K, Miyachi M.
  • Organizer: 58th American College of Sports Medicine
  • Place of Presentation: USA
  • Year and Date: 2011-06-03
• [Presentation] スポーツ・身体活動と遺伝子多型 (2010)
  • Author(s): 村上晴香
  • Organizer: 第80回東京体育学会研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-06
• [Presentation] 身体活動・運動行動に関連する遺伝的要因:ゲノムワイド解析 (2010)
  • Author(s): 村上晴香,家光素行,真田樹義,丸藤祐子,川上諒子,福典之,林貢一郎,宮地元彦
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-09-18
• [Presentation] 身体活動・運動行動に関連する遺伝的要因:ゲノムワイド解析 (2010)
  • Author(s): 村上晴香, ら
  • Organizer: 第65回 日本体力医学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-09-18
• [Book] Mitochondrial DNA Sequence Variation and Performance (2011)
  • Author(s): Kuno S, Zenpou H, Murakami H
• [Book] Mitochondrial DNA Sequence Variation and Performance. In Genetic and Molecular Aspects of Sports Performance.(Edited by Bouchard C.and Hoffman EP) (2011)
  • Author(s): Kuno, S., et al
  • Publisher: Wiley-Blackwell