| Project/Area Number |
22700749
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
TSUTSUMI Rie 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80510172)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ゴナドトロピン / mTOR / kisspeptin / レプチン / ゴナドロピン / FSH / LH / アミノ酸 / ロイシン |
|---|
| Research Abstract |
In this study, I demonstrated that the role of mTOR, which is well-known as a energy sensor of cells, and kisspeptin, is activated in downstream of mTOR, as a key modulator in the metabolic signaling and reproductive signaling. High-fat diet induced an increase of leptin level and decrease of mTOR activity and gonadotoropin secretion, whereas fasting also decreased gonadotoropin level and reproductive ability despite of leptin level was decreased.
|
