| Project/Area Number |
22700750
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
SHUTO Emi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10512121)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 生活習慣病 / 慢性炎症 / 動脈硬化 / 高リン血症 / リン / 心血管疾患 / 酸化ストレス |
|---|
| Research Abstract |
Excessive dietary phosphorus(P) has been speculated as a risk factor for cardiovascular disease(CVD) in healthy persons as well as in patients with chronic kidney disease. We reported that high P-loading increased production of reactive oxygen species and decrease nitric oxide(NO) availability in endothelial cells. In addition, we performed dose and time-dependent effect of dietary P intake on endothelial function in healthy male volunteers. High P meals significantly increased serum P levels in a dose-dependent manner, whereas significant decrease in% flow-mediated dilation(% FMD) was observed. Significant negative correlation was also observed between% FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people. Habitual excessive P intake and resulting in endothelial dysfunction may contribute to progress CVD or increasing mortality as epidemiologically speculated.
|
