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The institution of reference nutrient intake on phosphate, aimed prevention for the lifestyle-related disease

Research Project

Project/Area Number 22700750
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

SHUTO Emi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10512121)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生活習慣病 / 慢性炎症 / 動脈硬化 / 高リン血症 / リン / 心血管疾患 / 酸化ストレス
Research Abstract

Excessive dietary phosphorus(P) has been speculated as a risk factor for cardiovascular disease(CVD) in healthy persons as well as in patients with chronic kidney disease. We reported that high P-loading increased production of reactive oxygen species and decrease nitric oxide(NO) availability in endothelial cells. In addition, we performed dose and time-dependent effect of dietary P intake on endothelial function in healthy male volunteers. High P meals significantly increased serum P levels in a dose-dependent manner, whereas significant decrease in% flow-mediated dilation(% FMD) was observed. Significant negative correlation was also observed between% FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people. Habitual excessive P intake and resulting in endothelial dysfunction may contribute to progress CVD or increasing mortality as epidemiologically speculated.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] Suppression of Oral Tolerance by Lactococcus lactis in Mice2011

    • Author(s)
      Sakai T, Hirota Y, Nakamoto M, Shuto E, Hosaka T, Makino S, Ikegami S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 3 Pages: 599-601

    • DOI

      10.1271/bbb.100714

    • NAID

      10028202184

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice2011

    • Author(s)
      Sakai T, Furoku S, Nakamoto M, Shuto E, Hosaka T, Nishioka Y, Sone S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 3 Pages: 593-595

    • DOI

      10.1271/bbb.100710

    • NAID

      10028202155

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracts of Common Buckwheat Bran Prevent Sucrose Digestion2011

    • Author(s)
      Hosaka T, et al
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 57 Issue: 6 Pages: 441-445

    • DOI

      10.3177/jnsv.57.441

    • NAID

      130002103056

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary nucleic acid induces type 2 T-helper immune responsethrough toll-like receptor 9 in mice2011

    • Author(s)
      Nakamoto M., Shuto E., Hosaka T., and Sakai T.
    • Journal Title

      Eur. J. Nutr

      Volume: 50 Issue: 6 Pages: 421-426

    • DOI

      10.1007/s00394-010-0153-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice2010

    • Author(s)
      Sakai T, Furoku S, Nakamoto M, Shuto E, Hosaka T, Nishioka Y, Sone S
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 56 Issue: 1 Pages: 72-76

    • DOI

      10.3177/jnsv.56.72

    • NAID

      10025973044

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice2010

    • Author(s)
      Sakai T, et al
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 56(1) Pages: 72-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary deoxynucleic acid induces type 2 T-helper immune response through toll-like receptor 9 in mice2010

    • Author(s)
      Nakamoto M, et al
    • Journal Title

      Eur J Nutr.2010 Dec 4

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能への影響2010

    • Author(s)
      首藤恵泉、竹谷豊、大屋美穂、小河真理子、中西美咲、中本真理子、塩田あすか、北村知世、渡里恵梨子、阿望幾久子、保坂利男、山本浩範、酒井徹、武田英二
    • Organizer
      第64回日本栄養食糧学会大会
    • Place of Presentation
      アスティとくしま(徳島市)
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能への影響2010

    • Author(s)
      首藤恵泉
    • Organizer
      第64回 日本栄養・食糧学会大会
    • Place of Presentation
      徳島市
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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