| Budget Amount *help |
¥4,273,269 (Direct Cost: ¥3,287,130、Indirect Cost: ¥986,139)
Fiscal Year 2013: ¥503,269 (Direct Cost: ¥387,130、Indirect Cost: ¥116,139)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have previously reported that IDMs possessed abnormalities in insulin signaling and a fish oil-rich maternal diet improves cardiac Akt-related insulin signaling . In this study, we investigated the specific component in fish oil that was responsible for improving insulin signaling in primary cardiac muscle cells (PCMCs).
Pregnant diabetic rats were fed via gastric tube eicosapentaenoic acid(EPA group) or a control DDW (control). To examine changes in insulin signaling in the cardiac muscle in IDM, we isolated the heart and cultured PCMCs. The insulin signalling of the heart of IDM decreased, insulin resistance was induced. However, the impaired signalling has been improved by EPA medication during a diabetes mother's pregnancy. The protein of the heart of IDM exposed to hyperglycemia was saccharified highly.
The EPA in the fish oil may improve the impaired signaling pathway of the cardiac muscle of infants caused by a diabetic mother's hyperglycemia.
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