Association between obesity and circadian rhythm in nutritional immunology

• Project/Area Number: 22700762
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Azabu University
• Principal Investigator: SATO Natsuko 麻布大学, 生命・環境科学部, 准教授 (30398888)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,978,870 (Direct Cost: ¥3,829,900、Indirect Cost: ¥1,148,970); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,208,870 (Direct Cost: ¥929,900、Indirect Cost: ¥278,970); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肥満 / 食事リズム / 減量 / 脂肪細胞 / 概日リズム / 免疫

Research Abstract

We analyzed the association between chronotype, and immunity and inflammatory factor in obesity. Experimental 1; Liver and thymus weights were decreased in evening-type group of mice compared with ad-lib fed diet group of mice, although OVA (ovalbumin) specific antibodies were not different between morning-type, evening-type, and ad-lib fed diet groups. Experimental 2; Obesity were suppressed in morning-type high-fat diet group of mice compared with ad-lib fed high fat diet group of mice. Total activity counts in 24 hours were also changed by chronotype. These results suggested that chronotype is associated with obesity.