| Project/Area Number |
22700763
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Matsumoto University |
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Principal Investigator |
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| Research Collaborator |
SHIMOI Kayoko 静岡県立大学, 大学院・生活健康科学研究科, 教授 (10162728)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 健康と食生活 / ホルモン依存性がん / エストロゲン代謝 / がん化学予防 / フラボノイド / DNA損傷 / カテコールエストロゲン |
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| Research Abstract |
A dietary methoxyflavonoid, chrysoeriol, inhibited DNA damage induced by the carcinogenic endogenous estrogen metabolite, 4-OHE2.In a molecular docking analysis, chrysoeriol was found to fit well into the active site of CYP1B1, but not into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of this methoxyflavonoid. This indicates that such methoxyflavonoids may be a chemopreventive modulator involved in carcinogenesis such as in breast cancer.
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