| Project/Area Number |
22700770
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
BABA Ryoko 産業医科大学, 医学部, 講師 (90271436)
|
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
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| Keywords | 食物アレルギー / FcRn / 空腸 / 吸収上皮細胞 / トランスサイトーシス |
|---|
| Research Abstract |
Transcytosis of macromolecules including maternal IgG occurs in the jejunal absorptive cells of newborn and suckling mice. However, transcytosis disappeared after weaning. The transport system was mediated by neonatal Fc receptor (FcRn). The pattern of gene expression was varied among suckling and adult, proximal and distal small intestine.
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