Development of a novel functional food for overweight prevention based on the inhibition of ghrelin
| Project/Area Number |
22700772
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Nagasaki International University |
|---|
Principal Investigator |
NODAKE Yuich 長崎国際大学, 薬学部・生化学研究室, 助教 (30332282)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAKAKIBARA Ryuzo 長崎国際大学, 薬学部・生化学研究室, 教授 (30127229)
FUKASAWA Masashi 長崎国際大学, 薬学部・生化学研究室, 准教授 (20238439)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 薬学 / 食品 / 蛋白質 / 生理活性 / グレリン / グレリン受容体 / 摂食亢進ホルモン / 肥満予防 / 生活習慣病 / ホルモン-受容体相互作用 / 機能性食品 |
|---|
| Research Abstract |
The binding mechanism of ghrelin that is a hunger-stimulating hormone to its receptor(GHS-R) has many unknown aspects. In this study, I tried to construct a comprehensive evaluation system of the interaction between both molecules. GHS-R cDNA was obtained from RT-PCR using rat stomach total RNA. Four extracellular regions of GHS-R that were important for binding to ghrelin were amplified by PCR based on the GHS-R cDNA and inserted into the expression vector. The interaction between recombinant extracellular region proteins fixed on a sensor chip and ghrelin was evaluated by surface plasmon resonance analysis.
|
Report
(3 results)
Research Products
(15 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Patent(Industrial Property Rights)] 新規乳酸菌とそれを用いた肝細胞保護剤(保護成分)
Inventor(s)
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Industrial Property Rights Holder
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Related Report
