Analysis of regulatory mechanism and exploration of polyphenol which has anti-atherogenic effect through HDL

• Project/Area Number: 22700778
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: National Defense Medical College
• Principal Investigator: KONDO Harumi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (80401602)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: コレステロール / ポリフェノール / HDL / マクロファージ / 食事因子

Research Abstract

Reverse cholesterol transport (RCT) is pivotal in the return of excess cholesterol from peripheral tissues to the liver for excretion in bile and eventually feces. RCT from macrophages is a critical anti-atherogenicity mechanism of HDL. Coffee polyphenol; ferulic acid and anthocyanin showed to increase macrophage RCT in mice. In addition, we found that ferulic acid enhanced it in hamsters which have lipoprotein file like as human.

Research Products

• [Journal Article] プロテアソーム阻害によるコレステロール逆転送系の活性化に関する研究 (2014)
  • Author(s): 小倉正恒、綾織誠人、近藤春美、中家和宏、滝口俊一、薬師寺恵美、佐々木誠、小松知広、池脇克則
  • Journal Title: 防衛医科大学校雑誌 Volume: 39(1) Pages: 8-20
• [Journal Article] 食事因子と抗動脈硬化性リポ蛋白機能に関する研究 (2014)
  • Author(s): 近藤春美
  • Journal Title: 日本栄養・食糧学会誌 Volume: 67(1) Pages: 3-8
• [Journal Article] Hepatic Overexpression of Idol Increases Circulating Protein Convertase Subtilisin/Kexin Type 9 in Mice and Hamsters via Dual Mechanisms : Sterol Regulatory Element-Binding Protein 2 and Low-Density Lipoprotein Receptor-Dependent Pathways (2014)
  • Author(s): Sasaki M, Terao Y, Ayaori M, Uto-Kondo H, Iizuka M, Yogo M, Hagisawa K, Takiguchi S, Yakushiji E, Nakaya K, Ogura M, Komatsu T, Ikewaki K
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: (in press)
• [Journal Article] Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet (2014)
  • Author(s): Kawaguchi H, Yamada T, Miura N, Ayaori M, Uto-Kondo H, Ikegawa M, Noguchi M, Wang KY, Izumi H, Tanimoto A
  • Journal Title: J Atheroscler Thromb Volume: 21(3) Pages: 186-203
• [Journal Article] Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport (2013)
  • Author(s): Nakaya K, Ayaori M, Uto-Kondo H, Sotherden G M, Nishida T, Katamoto M, Miura Y, Takiguchi S, Yakushiji E, Iizuka M, Ogura M, Sasaki M, Yogo M, Komatsu T, Adachi T, Maruyama C, Ikewaki K
  • Journal Title: Biochim Biophys Acta Volume: 1831(8) Pages: 1402-1411
• [Journal Article] The study of reverse cholesterol transport by coffee polyphenol (2013)
  • Author(s): Uto-Kono H, Ayaori M, Ogura M, Nakaya K,Takiguchi S, Yakushiji E, Sasaki M, Ikewaki K
  • Journal Title: J Natl Def Med Coll Volume: 38(1) Pages: 1-15
• [Journal Article] Effects of nutraceuticals and botanicals on macrophage cholesterol efflux : Implications for atherosclerosis (2013)
  • Author(s): Sotherden G M, Uto-Kondo H, Ayaori M, Ikewaki K
  • Journal Title: J Nutr Ther Volume: 1(2) Pages: 96-106
• [Journal Article] The study of reverse cholesterol transport by coffee polyphenol. (2013)
  • Author(s): Uto-Kondo H, Ayaori M, Ogura M, Nakaya K,Takiguchi S, Yakushiji E, Sasaki M, Ikewaki K.
  • Journal Title: J Natl Def Med Coll. Volume: 38 Pages: 1-15
  • Peer Reviewed
• [Journal Article] Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages (2012)
  • Author(s): Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K
  • Journal Title: J Nutr Sci Vitam Volume: 58(2) Pages: 96-104
• [Journal Article] Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages (2012)
  • Author(s): Ayaori M, Yakushiji E, Ogura M, Nakaya K, Hisada T, Uto-Kondo H, Takiguchi S, Terao Y, Sasaki M, Komatsu T, Iizuka M, Yogo M, Uehara Y, Kagechika H, Nakanishi T, Ikewaki K
  • Journal Title: Biochim Biophys Acta Volume: 1821(4) Pages: 561-572
• [Journal Article] Effects of nutraceuticals and botanicals on macrophage cholesterol efflux: Implications for atherosclerosis. (2012)
  • Author(s): Sotherden G M, et al.
  • Journal Title: J Nutr Ther. Volume: 1 Pages: 96-106
  • Peer Reviewed
• [Journal Article] Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages. (2012)
  • Author(s): Iizuka M, et al.
  • Journal Title: J Nutr Sci Vitam. Volume: 58 Pages: 96-104
  • Peer Reviewed
• [Journal Article] Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway : findings from in vitro and ex vivo studies (2011)
  • Author(s): Ozasa H, Ayaori M, Iizuka M, Terao Y, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Uehara Y, Ogura M, Sasaki M, Komatsu T, Horii S, Uehara Y, Mochizuki S, Yoshimura M, Ikewaki K
  • Journal Title: Atherosclerosis Volume: 219(1) Pages: 141-150
• [Journal Article] Proteasomal inhibition promotes ABCA1 and ABCG1 expressions and cholesterol efflux from macrophages in vitro and in vivo (2011)
  • Author(s): Ogura M, Ayaori M, Terao Y, Hisada T, Iizuka M, Takiguchi S, Uto-Kondo H, Yakushiji E, Nakaya K, Sasaki M, Komatsu T, Ozasa H, Ohsuzu F, Ikewaki K
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31(9) Pages: 1980-1987
• [Journal Article] Effect of sulfonylurea agents on reverse cholesterol in vitro and in vivo (2011)
  • Author(s): Terao Y, Ayaori M, Ogura M, Yakushiji E, Uto-Kondo H, Hisada T, Ozasa H, Takiguchi S, Nakaya K, Sasaki M, Komatsu T, Iizuka M, Horii S, Ikewaki K
  • Journal Title: J Atherosclero Thromb Volume: 18(6) Pages: 513-530
• [Journal Article] Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo (2010)
  • Author(s): Nakaya K, Ayaori M, Uto-Kondo H, Hisada T, Ogura M, Yakushiji E, Takiguchi S, Terao Y, Ozasa H, Sasaki M, Komatsu T, Ohsuzu F, Ikewaki K
  • Journal Title: Atherosclerosis Volume: 213(1) Pages: 135-141
• [Journal Article] Coffee consumption enhances HDL mediated cholesterol efflux in macrophages (2010)
  • Author(s): Uto-Kondo H, Ayaori M, Ogura M, Nakaya K, Ito M, Suzuki A, Takiguchi SI, Yakushiji E, Terao Y, Ozasa H, Hisada T, Sasaki M, Ohsuzu F, Ikewaki K
  • Journal Title: Circ Res Volume: 106(4) Pages: 779-787
• [Presentation] ハムスターにおけるフェルラ酸のコレステロール逆転送作用に及ぼす影響 (2013)
  • Author(s): 近藤春美、綾織誠人、佐々木誠、余郷麻希子、小松知広、Grace Megumi Sotherden、池脇克則
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 愛知
  • Year and Date: 2013-05-25
• [Presentation] コーヒーポリフェノールがコレステロール逆転送作用に及ぼす影響-ハムスターにおける検討 (2013)
  • Author(s): 近藤春美、綾織誠人、余郷麻希子、佐々木誠、小松知広、Grace Megumi Sotherden、池脇克則
  • Organizer: 第45回日本動脈硬化学会
  • Place of Presentation: 東京
• [Presentation] Ezetimibe enhances macrophage reverse cholesterol transport in Golden Syrian hamsters (2012)
  • Author(s): Harumi Kondo, Makoto Ayaori, Makiko Yogo, Kazuhiro Nakaya, Makoto Sasaki, Maki Iizuka, Shunichi Takiguchi, Emi Yakushiji, Tomohiro Komatsu, Ikewaki Katsunori
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 福岡
• [Presentation] コレステロール負荷/吸収阻害が血清脂質およびコレステロール逆転送作用に及ぼす影響―ハムスターにおける検討 (2012)
  • Author(s): 近藤春美、綾織誠人、余郷麻希子、佐々木誠、滝口俊一、薬師寺恵美、飯塚麻貴、池脇克則
  • Organizer: 第65回日本栄養・食糧学会
  • Place of Presentation: 宮城
• [Presentation] Coffee consumption enhances HDL mediated cholesterol efflux in macrophages (2011)
  • Author(s): 近藤春美
  • Organizer: 第43回日本動脈硬化学会第19回若手研究者奨励賞
  • Place of Presentation: 北海道
  • Year and Date: 2011-07-15
• [Presentation] アスタキサンチンにおけるコレステロール逆転送作用に及ぼす影響 (2011)
  • Author(s): 飯塚麻貴、近藤春美, 他
  • Organizer: 第65回日本栄養・食糧学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] Anthocyanin enhances macrophage reverse cholesterol transport in mice (2011)
  • Author(s): Harumi Kondo, Makoto Ayaori, Kazuhiro Nakaya, Shunichi Takiguchi, Maki Iizuka, Takanori Tsuda, Emi Yakushiji, Yoshio Terao, Makoto Sasaki, Tomohiro Komatsu, Shunpei Horii, Ikewaki Katsunori
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: 北海道
• [Presentation] シトルリンはマクロファージからのコレステロール搬出を促進する (2011)
  • Author(s): 近藤春美、綾織誠人、小倉正恒、中家和宏、滝口俊一、薬師寺恵美、寺尾吉生、小笹英樹、井上弥絵、大鈴文孝、池脇克則
  • Organizer: 第65回日本栄養・食糧学会
  • Place of Presentation: 東京
• [Presentation] 食事因子と抗動脈硬化性リポ蛋白機能に関する研究
  • Author(s): 近藤春美
  • Organizer: 第67回日本栄養・食糧学会
  • Place of Presentation: 名古屋大学
  • Invited
• [Presentation] ハムスターにおけるフェルラ酸のコレステロール逆転送作用に及ぼす影響
  • Author(s): 近藤春美、綾織誠人、佐々木誠、余郷麻希子、小松知広、Grace Megumi Sotherden、池脇克則
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 名古屋大学
• [Presentation] コーヒーポリフェノールがコレステロール逆転送作用に及ぼす影響－ハムスターにおける検討
  • Author(s): 近藤春美、綾織誠人、余郷麻希子、佐々木誠、小松知広、Grace Megumi Sotherden、池脇克則
  • Organizer: 第45回日本動脈硬化学会
  • Place of Presentation: 京王プラザホテル
• [Presentation] コーヒーポリフェノールによる HDL（善玉コレステロール）を介した抗動脈硬化作用
  • Author(s): 近藤春美
  • Organizer: 第16回コーヒーサイエンスセミナー
  • Place of Presentation: 学士会館21
  • Invited
• [Presentation] 食事因子と抗動脈硬化性リポ蛋白機能に関する研究
  • Author(s): 近藤春美
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 名古屋大学
  • Invited
• [Presentation] ハムスターにおけるフェルラ酸のコレステロール逆転送作用に及ぼす影響
  • Author(s): 近藤春美
  • Organizer: 第66回日本栄養・食糧学会
  • Place of Presentation: 名古屋大学
• [Presentation] コーヒーポリフェノールがコレステロール逆転送作用に及ぼす影響－ハムスターにおける検討
  • Author(s): 近藤春美
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 京王プラザホテル
• [Book] 抗動脈硬化性リポ蛋白としてHDL を考察する: real or fake?, Vascular Medicine, 10巻1号 (2014)
  • Author(s): 綾織誠人、近藤春美、池脇克則
• [Book] French Paradox、動脈硬化予防、13巻1号(3月) (2014)
  • Author(s): 近藤春美、池脇克則
• [Book] コーヒー摂取による抗動脈硬化作用、日本臨床、71巻3号 (2013)
  • Author(s): 近藤春美、綾織誠人
• [Book] HDL コレステロールが低い症例、臨床栄養、122巻6号 (2013)
  • Author(s): 綾織誠人、小倉正恒、近藤春美
• [Book] 日本臨床増刊号脂質異常症 (2013)
  • Author(s): 近藤春美、綾織誠人
  • Total Pages: 5
  • Publisher: 株式会社 日本臨床社
• [Book] 日本臨床 (2013)
  • Author(s): 近藤春美
  • Publisher: (株)日本臨床社
• [Book] Is Coffee the Next Red Wine? : Coffee polyphenol and cholesterol efflux. Coffee : Emerging Health Effects and Disease Prevention (2012)
  • Author(s): Harumi Kondo, Makoto Ayaori, Katsunori Ikewaki
  • Publisher: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd), NY
• [Book] Coffee : Emerging Health Effects and Disease Prevention (2012)
  • Author(s): Harumi Kondo, et al
  • Total Pages: 4
  • Publisher: John Wiley & Sons Ltd