The role of PIK3C3 in cell proliferation and tumor development

• Project/Area Number: 22700861
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Carcinogenesis
• Research Institution: Akita University
• Principal Investigator: EGUCHI Satoshi 秋田大学, 大学院・医学系研究科, 助教 (70457117)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: イノシトールリン脂質 / ノックアウトマウス / 細胞増殖 / 癌

Research Abstract

The role of PIK3C3 in cell proliferation and tumor development remains unclear. We generated knockout mice to analyze the physiological functions of PIK3C3. The deletion of PIK3C3 significantly suppressed cell proliferation and reduced the production of PI3P. In addition, PIK3C3 is necessary for starvation-induced autophagy. In adult mice, the ablation of PIK3C3 suppressed tumor development caused by Pten deletion in immune systems.

Research Products

• [Journal Article] The PtdIns(3,4)P_2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death Nature (2010)
  • Author(s): Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T
  • Volume: 465
  • Pages: 497-501
  • Peer Reviewed
• [Journal Article] The PtdIns(3,4)P_2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death (2010)
  • Author(s): Sasaki J., Kofuji S., et al.
  • Journal Title: Nature Volume: 465 Pages: 497-501
  • Peer Reviewed
• [Presentation] クラス3ホスファチジルイノシトール3キナーゼの免疫系での役割 (2011)
  • Author(s): 江口賢史, 佐々木純子, 伊藤玲悦, 浅沼研, 佐々木雄彦
  • Organizer: 第9回北東北血液研究会
  • Place of Presentation: 秋田市
  • Year and Date: 2011-05-14
• [Presentation] クラス3ホスファチジルイノシトール3キナーゼの免疫系での役割 (2011)
  • Author(s): 江口賢史
  • Organizer: 第9回北東北血液研究会
  • Place of Presentation: 秋田県さとみ温泉
  • Year and Date: 2011-05-14
• [Presentation] PIK3C3の生理的意義の解析 (2010)
  • Author(s): 江口賢史, 佐々木純子, 小藤智史, 佐々木雄彦
  • Organizer: 第4回グローバルGCOE若手研究者シンポジウム
  • Place of Presentation: 秋田市
  • Year and Date: 2010-11-16
• [Presentation] ホスホイノシチド代謝酵素と生理機能 (2010)
  • Author(s): 佐々木雄彦, 佐々木純子, 高須賀俊輔, 江口賢史, 小藤智史
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-21