Regulation of liver tumor development by Mats gene

• Project/Area Number: 22700864
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Carcinogenesis
• Research Institution: Kyushu University
• Principal Investigator: WANG Jia 九州大学, 稲盛フロンティア研究センター, 学術研究員 (60572245)
• Co-Investigator(Renkei-kenkyūsha): 鈴木 聡 九州大学, 生体防御医学研究所
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Hippoシグナル経路 / Mats / 肝臓癌 / HIPPO / 肝臓 / Yap / 肝実質細胞癌 / 胆内胆管癌 / オバール細胞 / 肝内胆管上皮細胞癌 / 肝癌

Research Abstract

Recent studies in Drosophila suggest that the Hippo intracellular signaling pathway plays an important role in the control of organ size, cell proliferation, and tumor development. Central to the Hippo pathway is the kinase cascade consisting of Mst kinase, WW45, Lats kinase, and its regulatory subunit Mats. Lats associates with Mats to restrict cell proliferation primarily by regulating Yap/Taz, the primary downstream effector of the Hippo pathway. We have generated Mats1/2 mutant mice, and found that Mats1/2 are important for the embryogenesis and tumor regulation. In addition, we found that all of liver-specific Mats1/2 deficient mice showed liver tumors. Chemicals targeting the Hippo pathway including Mats, may become the new drugs for the treatment of tumors.

Research Products

• [Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 (2011)
  • Author(s): Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori & Akira Suzuki
  • Journal Title: Nature Medicine Volume: 17 Pages: 944-951
• [Presentation] 「がん研究支援班」 (2011)
  • Author(s): 西尾美希、濱田浩一、王嘉、伊東文祥、河原康一、佐々木雅人、鈴木聡
  • Organizer: 個体レベル研究のワークショップ
  • Place of Presentation: 大津
• [Presentation] Hippo経路遺伝子MOB1による発癌制御 (2010)
  • Author(s): 鈴木聡, et al.
  • Organizer: 第69回日本癌学会学術集会シンポジウム
  • Place of Presentation: 大阪 リーガルホテル
  • Year and Date: 2010-09-24
• [Presentation] 、The role of the tumor suppressor gene MATS1(Mob1) in the Hippo signaling pathway (2010)
  • Author(s): 西尾美希、濱田浩一、佐々木雅人、伊東文祥、王嘉、小西弘晃、河原康一、佐々木雅彦、鈴木聡
  • Organizer: 第69回日本癌学会学術集会
  • Place of Presentation: 大阪