| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
I found that auto-cleavage of separase, a protease that is inhibited by securin, is crucial for the proper regulation of separase activity, and the timely chromosome segregation. I also showed that a disturbance of the chromosome stability plays a role in the cell transformation induced by over-expression of securin. These data demonstrate the relationship between the function of separase-securin for the stable chromosome segregation and the tumor development.
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