Tumorigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-beta.

• Project/Area Number: 22700876
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: The University of Tokyo
• Principal Investigator: EHATA Shogo 東京大学, 大学院・医学系研究科, 助教 (90506726)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: TGF-beta / スキルス胃癌 / 癌幹細胞 / ABCG2/BCRP / ALDH1 / TGF-β

Research Abstract

ALDH1+cells, constituted 5-8% of the human diffuse-type gastric carcinoma cells, were more tumourigenic and able to self-renew and generate heterogeneous cell populations. Using gene expression microarray analyses, we identified REG4 as a novel marker for cancer-initiating cells. Targeting REG4 in cancer cells may provide a novel strategy in the treatment of diffuse-type gastric carcinoma.

Research Products

• [Journal Article] Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-β (2012)
  • Author(s): Katsuno Y
  • Journal Title: J Pathol Volume: 228 Issue: 3 Pages: 391-404
  • DOI: 10.1002/path.4020
  • Peer Reviewed
• [Journal Article] Tumor-promoting functions of transforming growth factor-β in progression of cancer (2012)
  • Author(s): Miyazono K
  • Journal Title: Ups J Med Sci Volume: 117 Issue: 2 Pages: 143-152
  • DOI: 10.3109/03009734.2011.638729
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-2/4 play tumor suppressive roles in human diffuse-type gastric carcinoma (2011)
  • Author(s): Shirai YT、Ehata S、Yashiro M、Yanagihara K、Hirakawa K、Miyazono K
  • Journal Title: Amerian Journal of Pathology Volume: Vol.179、No.6 Pages: 2920-2930
  • URL: http://dx.doi.org/10.1016/j.ajpath.2011.08.022
  • Peer Reviewed
• [Journal Article] Transforming growth factor-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells (2011)
  • Author(s): Ehata S、Johansson E、Katayama R、Koike S、Watanabe A、Hoshino Y、Katsuno Y、Komuro A、Koinuma D、Kano MR、Yashiro M、Hirakawa K、Aburatani H、Fujita N、Miyazono K
  • Journal Title: Oncogene Volume: Vol.30、No.14 Issue: 14 Pages: 1693-1705
  • DOI: 10.1038/onc.2010.546
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma (2011)
  • Author(s): Shirai YT
  • Journal Title: American Journal of Pathology Volume: 179 Issue: 6 Pages: 2920-2930
  • DOI: 10.1016/j.ajpath.2011.08.022
  • Peer Reviewed
• [Journal Article] Transforming growth factor-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells (2011)
  • Author(s): 江幡正悟
  • Journal Title: Oncogene Volume: (掲載確定(印刷中))
  • Peer Reviewed
• [Journal Article] 胃癌におけるTGF-βシグナルの役割 (2010)
  • Author(s): 江幡正悟
  • Journal Title: 週刊 医学のあゆみ Volume: 10号 Pages: 937-941
• [Presentation] Cancer-initiating cell population in diffuse-type gastric carcinoma cells has high ALDH1 activity (2011)
  • Author(s): Yoko Katsuno、Shogo Ehata、Masakazu Yashiro、Kazuyoshi Yanagihara、Kosei Hirakawa、Kohei Miyazono
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] Bone morphogenetic protin-2/4 play tumor suppressive roles in human diffuse-type gastric carcinoma (2011)
  • Author(s): Yo-taro Shirai、Shogo Ehata、Masakazu Yashiro、Kosei Hirakawa、Kohei Miyazono
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] Cancer-initiating cell population in diffuse-type gastric carcinoma cells has high ALDH1 activity (2011)
  • Author(s): 勝野蓉子
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-05
• [Presentation] TGF-beta diminishes the Side Population fraction of the diffuse-type gastric cancer cells (2011)
  • Author(s): Shogo Ehata、Erik Johansson、Ryohei Katayama、Sumie Koike、Akira Watanabe、Yukari Hoshino、Yoko Katsuno、Akiyoshi Komuro、Daizo Koinuma、Mitsunobu R. Kano、Masakazu Yashiro、Kosei Hirakawa、Hiroyuki Aburatani、Naoya Fujita、Kohei Miyazono
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2011-04-30
• [Presentation] TGF-beta diminishes the SP fraction of the diffuse-type gastric carcinoma cells (2010)
  • Author(s): Shogo Ehata、Ryohei Katayama、Sumie Koike、Yukari Hoshino、Yoko Katsuno、Daizo Koinuma、Mitsunobu Kano、Masakazu Yashiro、Kosei Hirakawa、Naoya Fujita、Kohei Miyazono
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪府大阪市大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] Cancer-initiating cell population in diffuse-type gastric carcinoma cells has high ALDH1 activity (2010)
  • Author(s): Yoko Katsuno、Shogo Ehata、Masakazu Yashiro、Kosei Hirakawa、Kohei Miyazono
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪府大阪市大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] TGF-beta diminishes the SP fraction of the diffuse-type gastric carcinoma cells. (2010)
  • Author(s): 江幡正悟
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: リーガロイヤルホテル大阪(大阪府 大阪市)
  • Year and Date: 2010-09-23
• [Presentation] BMP plays a tumor suppressive role in diffuse-type gastric carcinoma development (2010)
  • Author(s): Yo-Taro Shirai、Shogo Ehata、Masakazu Yashiro、Kosei Hirakawa、Kohei Miyazono
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪府大阪市大阪国際会議場
  • Year and Date: 2010-09-22
• [Book] 胃癌におけるTGF-betaシグナルの役割、別冊「医学のあゆみ」TGF-betaシグナル研究、メカニズムの解明から新たな治療へ (2011)
  • Author(s): 江幡正悟
  • Publisher: 医歯薬出版株式会社
• [Remarks] (東京大学・大学院医学系研究科・病因病理学専攻・分子病理学分野ホームページ)
  • URL: http://beta-lab.umin.ac.jp/
• [Remarks]
  • URL: http://beta-lab.umin.ac.jp/