Tumorigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-beta.
| Project/Area Number |
22700876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
EHATA Shogo 東京大学, 大学院・医学系研究科, 助教 (90506726)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | TGF-beta / スキルス胃癌 / 癌幹細胞 / ABCG2/BCRP / ALDH1 / TGF-β |
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| Research Abstract |
ALDH1+cells, constituted 5-8% of the human diffuse-type gastric carcinoma cells, were more tumourigenic and able to self-renew and generate heterogeneous cell populations. Using gene expression microarray analyses, we identified REG4 as a novel marker for cancer-initiating cells. Targeting REG4 in cancer cells may provide a novel strategy in the treatment of diffuse-type gastric carcinoma.
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Report
(3 results)
Research Products
(18 results)
