| Project/Area Number |
22700877
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TSUTSUMI Ryohei 東京大学, 大学院・医学系研究科, 助教 (50435872)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん / チロシンホスファターゼ / SHP2 / parafibromin / ホスファターゼ |
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| Research Abstract |
Tyrosine phosphatase SHP2 has been identified as an oncoprotein, which is involved in juvenile leukemia and solid tumor. In this study, SHP2 substrates were explored to clarify the molecular mechanisms how SHP2 causes carcinogenesis. As result, I identified a nuclear protein, parafibromin, which plays important roles in gene transcription machinery, as a novel substrate of SHP2. Furthermore, dephosphorylation of parafibromin by SHP2 activates Wnt pathway, which is an important pathway in carcinogenesis.
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