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Involvement of organic anion transporter OAT1 on the chemo-sensitivity in renal cancer cells

Research Project

Project/Area Number 22700886
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Tumor biology
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

SUZUKI Eriko  東京農工大学, (連合)農学研究科(研究院), 助教 (00468513)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsがん細胞の特性 / 薬剤感受性 / トランスポーター / 化学療法 / 腎癌 / SLCトランスポーター
Research Abstract

Kidney cancer cells are usually resistant to chemotherapy, therefore chemotherapy has not been a standard treatment for kidney cancer. We focused on organic aniontransporter OAT1 expressed in renal glomerular endothelial cells and involved in resorption of general drug. Our study demonstrated that OAT1 expressing kidney cancer cells exhibits increased cell death concomitant with increased incorporation of anionic cancer drug including vincristine. In vivo imaging using EGFP-OAT1 overexpressing cells was first planned, however it was abandoned due to the absense of appropriate image-capturing system.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (1 results)

All 2010

All Presentation (1 results)

  • [Presentation] 腎癌細胞における有機アニオントランスポーターOAT1の薬剤感受性への寄与2010

    • Author(s)
      鈴木絵里子、菊池栄次、三上修司、大家基嗣
    • Organizer
      日本泌尿器科学会(JUA)
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-21
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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