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Studies on selective translation mechanism of stress response Protein under global translational repression

Research Project

Project/Area Number 22700892
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Tumor biology
Research Institution公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010)

Principal Investigator

TSUKUMO Yosinori  公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 (40469630)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords翻訳 / ストレス応答タンパク / 小胞体 / mRNA / リボソーム / 翻訳開始因子 / 腫瘍 / 飢餓
Research Abstract

Upon endoplasmic reticulum(ER) stress, PKR-like ER-resident kinase(PERK) phosphorylates eukaryotic translation initiation factor 2 alpha(eIF2α), resulting in reducing global translation while promoting translation reinitiation of upstream open reading frame(uORF)-containing mRNAs, such as ATF4.We showed transducin(beta)-like 2(TBL2) as a novel ER-anchored adaptor protein that promotes the PERK-mediated translation reinitiation for cell survival.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation2012

    • Author(s)
      Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
    • Journal Title

      Mol Cancer Ther

      Volume: 11(5) Issue: 5 Pages: 1082-1091

    • DOI

      10.1158/1535-7163.mct-11-0871

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation2012

    • Author(s)
      Junichi Matsuo, Yoshinori Tsukumo (co-first), et al
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 11 Pages: 1082-91

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ビグアナイド系化合物による4E-BP1の活性化と抗腫瘍効果2011

    • Author(s)
      築茂由則、近藤裕道、冨田章弘
    • Organizer
      分指標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Hyper-activation of 4E-binding protein 1 by anti-diabetic biguanide as its anti-tumor mechanisms of action2011

    • Author(s)
      Yoshinori Tsukumo, Junichi Matsuo, Satomi Tsukahara, Junko Sakurai, Toshiki Watanabe, Sigeo Sato, Hiromichi Kondo, and Akihiro Tomida
    • Organizer
      American Association for Cancer Research, Special conference
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2011-02-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Hyper-activation of 4E-binding protein 1 by anti-diabetic biguanide as its anti-tumor mechanisms of action2011

    • Author(s)
      築茂由則
    • Organizer
      American Association for Cancer Research, Special conference, "Targeting PI3K/mTOR signaling in cancer"
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビグアナイド系化合物による4E-BP1の活性化と抗腫瘍効果2011

    • Author(s)
      築茂由則
    • Organizer
      分子標的治療学会
    • Place of Presentation
      東京ホテル日航東京
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/chemotherapy/department/genome/index.html

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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