Innovative development of antibody drug with ultrastructural in vivo imaging
Project/Area Number |
22700895
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Tumor immunology
|
Research Institution | Tohoku University |
Principal Investigator |
GONDA Kohsuke 東北大学, 大学院・医学系研究科, 講師 (80375435)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 抗体療法 / 蛍光 / ナノイメージング / CT / ナノ粒子 / in vivo / ex vivo / 抗体医薬 / がん |
Research Abstract |
To develop antibody drug with cheap and high medicinal effect, this study aimed to visualize and analyze where and how the effect of antibody drug works in the tumor tissues using 3D imaging with high spatial accuracy. I performed fluorescence in vivo and ex vivo imaging and CT imaging, and then aimed to integrate each imaging data. I succeeded in developing new in vivo imaging system, ex vivo imaging 50μm thickness tumor tissues whose cancer cells activity were well, and CT-imaging with new slica-coating gold nano-particles. Now I am imaging tumor-bearing mice with antibody drug-conjugated fluorescent nano-particles or antibody drug-conjugated slica-coating gold nano-particles using fluorescence in vivo and ex vivo imaging or CT imaging. As the results of these, I obtained a preliminary result in the relationship between EPR effect and antibody drug effect.
|
Report
(3 results)
Research Products
(55 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 生物物理2011
Author(s)
権田幸祐, 渡邉朋信, 大内憲明, 樋口秀男
Publisher
がん転移の生体ナノイメージング
Related Report
-
-
-
-
-
[Book] ナノ学会会報2010
Author(s)
日景允, 権田幸祐, 武田元博, 亀井尚, 小林正樹, 熊坂増高, 濱中洋平, 濱田庸, 中川智彦, 宮田剛, 大内憲明
Publisher
量子ドットを用いたリンパネットワークの微細構造イメージング
Related Report
-
[Book] 東北医学会雑誌2010
Author(s)
日景允, 権田幸祐, 武田元博, 亀井尚, 大内憲明
Publisher
Fluorescent sentinel lymph node biopsy under endoscopic surgery using nano-objects
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-