Identification of novel master gene controlling memory CD4+ T cell for improving cancer immunotherapy
| Project/Area Number |
22700896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor immunology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIKI Fumihiro 大阪大学, 大学院・医学系研究科, 特任助教(常勤) (40456926)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | ヘルパーT細胞 / メモリーT細胞 / 癌免疫療法 / WT1 / エフェクターT細胞 / マスター遺伝子 / CD4+ヘルパーT細胞 |
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| Research Abstract |
The induction of tumor-associated antigens(TAAs)-specific CD4+ helper T cell(Th cell) and its maintenance are essential for ideal cancer immunotherapy. However, mechanism of memory T cell development remains unclear. In this study, we focused on heterogeneity of WT1(one of TAAs)-specific Th clone and identified two genes, which were specifically overexpressed in memory T cell or effector T cell. Since there is no report regarding function of these genes in T cell, we generated the identified genes-knockout/ knockin mice.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Biased usage of BV gene families of T-cell receptors of WT1(Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies2010
Author(s)
Tanaka-Harada Y, Kawakami M, Oka Y, Tsuboi A, Katagiri T, Elisseeva OA, Nishida S, Shirakata T, Hosen N, Fujiki F, et al.(他6名、10番目)
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Journal Title
Cancer Sci
Volume: 101
Issue: 3
Pages: 594-600
DOI
NAID
Related Report
Peer Reviewed
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