| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We have established the intravital multi-photon imaging system for monitoring the cell behavior of antigen-specific cytotoxic T cells and endogenous dendritic cells in living mouse lymph node and tumor. By using this system, we have visualized the entire process of T cell activation through interactions with endogenous dendritic cells, and identified a dendritic cell subset responsible for antigen presentation selectively to cytotoxic T cells. Furthermore, we have found antigen-specific interactions between tumor-infiltrating effector-cytotoxic T cells and tumor-surrounding dendritic cells, suggesting a new mechanism for inducing T cell proliferation and differentiation not only at the secondary lymphoid organs, but also at the effector sites such as tumor lesion.
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