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Development of high accuracy, high sensitivity, and rapid diagnosis system for thyroid carcinoma using nano particles

Research Project

Project/Area Number 22700906
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Tumor diagnosis
Research InstitutionJikei University School of Medicine

Principal Investigator

FUJIOKA Kouki  東京慈恵会医科大学, 医学部, 助教 (90392381)

Research Collaborator TAKEYAMA Hiroshi  東京慈恵会医科大学, 医学部, 准教授 (70236511)
MANOME Yoshinobu  東京慈恵会医科大学, 医学部, 教授 (30219539)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords腫瘍マーカー / 甲状腺癌 / ナノ粒子 / 新規診断法の開発 / 癌 / ナノ材料 / 量子ドット / 診断 / 甲状腺
Research Abstract

We developed biomedical applications using the combination of high-intensity fluorescent nanoparticles, quantum dots(QDs), and JT-95 monoclonal antibody, which recognizes the antigen of thyroid carcinomas. Toward to the practice use of these applications in medical fields, we have been studying the accuracy of detection system.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 Other

All Journal Article (1 results) Presentation (6 results) Remarks (5 results)

  • [Journal Article] Conjugation of Quantum Dots and JT95 IgM Monoclonal Antibody for Thyroid Carcinoma Without Abolishing the Specificity and Activity of the Antibody2011

    • Author(s)
      Watanabe, M., Fujioka, K., Akiyama, N., Takeyama, H., Manabe, N., Yamamoto, K., Manome, Y.
    • Journal Title

      IEEE Transactions on NanoBioscience

      Volume: 10(1) Issue: 1 Pages: 30-35

    • DOI

      10.1109/tnb.2011.2125800

    • Related Report
      2011 Final Research Report
  • [Presentation] 甲状腺癌細胞株の糖鎖構造の解析2011

    • Author(s)
      藤岡宏樹、池田惠一、武山浩、馬目佳信
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 甲状腺癌細胞株の糖鎖構造の解析2011

    • Author(s)
      藤岡宏樹、池田恵一、武山浩、馬目佳信
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 甲状腺癌を特異的に検出する抗体(JT95)を用いた生化学アプリケーション2011

    • Author(s)
      藤岡宏樹、渡邊美智子、武山浩、馬目佳信
    • Organizer
      Conference for Bio-Signal and Medicine 2011
    • Place of Presentation
      長野
    • Year and Date
      2011-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Biochemical Application of Thyroid Carcinoma Specific Antibody (JT95)2011

    • Author(s)
      Kouki Fujioka, Michiko Watanabe, Hiroshi Takeyama, Yoshinobu Manome
    • Organizer
      Conference for Bio-Signal and Medicine (CBSM) 2011
    • Place of Presentation
      軽井沢プリンスホテルウエスト(長野県)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 甲状腺がん特異的抗体JT95と、蛍光ナノ粒子QDによる新規検出法の開発2010

    • Author(s)
      藤岡宏樹、真鍋法義、野村真弓、渡辺美智子、花田三四郎、星野昭芳、山本健二、馬目佳信、武山浩
    • Organizer
      第53回日本甲状腺学会学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2010-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 甲状腺がん特異的抗体JT95と、蛍光ナノ粒子QDによる新規検出法の開発2010

    • Author(s)
      藤岡宏樹、真鍋法義、野村真弓、渡辺美智子、花田三四郎、星野昭芳、山本健二、馬目佳信、武山浩
    • Organizer
      第53回日本甲状腺学会学術集会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.jikei.ac.jp/academic/course/19_bunsisaibo.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://jikei-dna.jp/section/cell.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.jikei.ac.jp/univ/gradu/rsch/06_05.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://jikei-dna.jp/section/cell.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.jikei.ac.jp/univ/gradu/rsch/06_05.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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