| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Using microarrays, we identified the microRNAs characteristically expressed in EGFR mutated, KRAS mutated, and ALK translocated lung adenocarcinomas, respectively. Furthermore, we identified characteristic pathways for the microRNAs of EGFR mutated, KRAS mutated, and ALK translocated lung adenocarcinomas, respectively. On the other hand, small cell lung carcinomas(SCLCs) were classified into two groups(SCLC1 and SCLC2) by hierarchical clustering using microRNA microarray. SCLC1, which formed an independent cluster comprising only SCLCs, has a significant poorer prognosis than SCLC2, which clustered with lung adenocarcinomas(P=0.039). Further investigations, in silico and in vitro, are required to validate these results.
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