Mechanism of tumor specific porphyrin accumulation after administration of aminolevulinic acid

• Project/Area Number: 22700910
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Tumor diagnosis
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: OGURA Shun-ichiro 東京工業大学, フロンティア研究機構, 特任准教授 (90343160)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: がんの個性診断 / バイオマーカー / 5-アミノレブリン酸 / プロトポルフィリンIX / PEPT1 / ABCG2 / ミトコンドリア / 治療効果予測因子 / 好気代謝

Research Abstract

Recently, aminolevulinic acid-based photodynamic therapy(ALA-PDT) is being widely used in cancer therapy owing to the tumor-specific accumulation of photosensitizing protoporphyrin IX(PpIX) after the administration of ALA. In the present study, by focusing on genes involved in the porphyrin biosynthesis pathway, we aimed to explore biomarkers that are predictive for the efficacy of ALA-PDT. We found that high expression of the peptide transporter PEPT1(ALA influx transporter) and low expression of the ATP-binding cassette transporter ABCG2(porphyrin efflux transporter) determined ALA-induced PpIX production and cellular photosensitivity in vitro. Thus, it is suggested that PEPT1 and ABCG2 are potential biomarkers to predict the selective porphyrin accumulation after ALA administration.

Research Products

• [Journal Article] Tumor Suppressor Protein p53-dependent Cell Death Induced by 5-Aminolevulinic Acid (ALA)-based Photodynamic Sensitization of Cancer cells in Vitro (2012)
  • Author(s): Hagiya Y., Endo Y., Yonemura Y., Okura I., Ogura S.
  • Journal Title: ALA-Porphyrins Science Volume: (In press)
  • Peer Reviewed
• [Journal Article] Improvement of tumor localization of photosensitizers for photodynamic therapy and its application for tumor diagnosis (2012)
  • Author(s): Ogura S., Hagiya Y., Tabata K, Kamachi T., Okura I.
  • Journal Title: Current Topics in Medicinal Chemistry Volume: 12(3) Pages: 176-184
  • Peer Reviewed
• [Journal Article] Pivotal Roles of Peptide Transporter PEPT1 and ATP-Binding Cassette (ABC) Transporter ABCG2 in 5-Aminolevulinic Acid (ALA)-Based Photocytotoxicity of Gastric Cancer CeUs in Vitro (2012)
  • Author(s): Hagiya Y., Endo Y., Yonemura Y., Takahashi K., Ishizuka M., Abe F, Tanaka T., Okura I., Nakajima M., Ishikawa T., Ogura S
  • Journal Title: Photodiagnosis and Photodynamic Therapy Volume: (In press)
  • Peer Reviewed
• [Journal Article] Aminolevulinic acid and porphyrin biosynthesis, Aminolevulinic acid(Edited by Ichiro Okura and Tohru Tanaka) (2011)
  • Author(s): Shun-ichiro Ogura
  • Journal Title: SBI ALApromo Pages: 3-9
  • Peer Reviewed
• [Journal Article] Photodynamic screening of tumors using aminolevulinic acid, Aminolevulinic acid(Edited by Ichiro Okura and Tohru Tanaka) (2011)
  • Author(s): Shun-ichiro Ogura
  • Journal Title: SBI ALApromo Pages: 169-176
  • Peer Reviewed
• [Journal Article] Masayasu Mie, Eiry Kobatake Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX (2011)
  • Author(s): Takao Kunii, Shun-ichiro Ogura, Masayasu Mie, Eiry Kobatake
  • Journal Title: Analyst Volume: 136 Pages: 1310-1312
  • Peer Reviewed
• [Journal Article] Identification of a novel protein isoform derived from cancer-related splicing variants using combined analysis of transcriptome and proteome (2011)
  • Author(s): Keiichi Hatakeyama, Keiichi Ohshima, Yorikane Fukuda, Shun-ichiro Ogura, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
  • Journal Title: Proteomics Volume: 11 Pages: 2275-82
  • Peer Reviewed
• [Journal Article] The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver (2011)
  • Author(s): Shun-ichiro Ogura, Kouji Maruyama, Yuichiro Hagiya, Yuta Sugiyama, Kyoko Tsuchiya, Kiwamu Takahashi, Fuminori Abe, Kenji Tabata, IchiroOkura, Motowo Nakajima, Tohru Tanaka
  • Journal Title: BMC Research Notes Volume: 4 Pages: 66-66
  • Peer Reviewed
• [Journal Article] Porphyrins in mouse urine after administration of 5-aminolevulinic acid as a potential tumor marker (2011)
  • Author(s): Yasuhiro Mizokami, Kanako Honda, Kenji Tabata, Toshiaki Kamachi, Kiwamu Takahashi, Fuminori Abe, Tohru Tanaka, Motowo Nakajima, Shun-ichiro Ogura and Ichiro Okura
  • Journal Title: Photodiagnosis and Photodynamic Therapy Volume: 8 Pages: 328-331
  • Peer Reviewed
• [Journal Article] Potential for cancer diagnosis by porphyrin determination after 5-aminolevulinic acid(ALA) administration-Establishment of a porphyrin determination method (2011)
  • Author(s): Masahiro Ishizuka, Yasunobu Ueda, Satoshi Utsugi, Shun-ichiro Ogura, Masao Kondo and Ichiro Okura
  • Journal Title: Porphyrins Volume: 19(2-3) Pages: 11-19
  • Peer Reviewed
• [Journal Article] Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors : CPOX expression and 5-ALA-induced fluorescence (2011)
  • Author(s): Kenkichi Takahashi, Naokado Ikeda, Naosuke Nonoguchi, Yoshinaga Kajimoto, Shin-ichi Miyatake, Yuichiro Hagiya, Shun-ichiro Ogura, Hiroshi Nakagawa, Toshihisa Ishikawa and Toshihiko Kuroiwa
  • Journal Title: Neuro-oncology Volume: 13(11) Pages: 1234-43
  • Peer Reviewed
• [Journal Article] New development of 5-aminolevurinic acid(ALA) in cancer diagnoses and therapy (2011)
  • Author(s): Masahiro Ishizuka, Fuminori Abe, Yuki Sano, Kiwamu Takahashi, Katsushi Inoue, Motowo Nakajima, Takeo Kohda, Naoki Komatsu, Shun-ichiro Ogura and Tohru Tanaka
  • Journal Title: International Immunopharmacology Volume: 11 Pages: 358-365
  • Peer Reviewed
• [Journal Article] 5-アミノレブリン酸を用いたPDD、PDTの現状と将来 (2011)
  • Author(s): 田中徹、石塚昌宏、小倉俊一郎、井上克司
  • Journal Title: Japanese Journal of Endourology Volume: 24 Pages: 39-34
  • NAID: 10030921737
  • Peer Reviewed
• [Journal Article] Current states and future views in photodynamic therapy, Journal of Photochemistry and Photobiology C (2011)
  • Author(s): Shigenobu Yano, Shiho Hirohara, Makoto Obata, Yuichiro Hagiya, Shun-ichiro Ogura, Atsushi Ikeda, Hiromi Kataoka, Mamoru Tanaka and Takashi Joh
  • Journal Title: Photochemistry Reviews Volume: 12(1) Pages: 46-67
  • Peer Reviewed
• [Journal Article] Transporter-Mediated drug interaction strategy for 5-aminolevulinic acid(ALA)-based photodynamic diagnosis of malignant brain tumor : molecular design of ABCG2 inhibitors (2011)
  • Author(s): Toshihisa Ishikawa, Kenkichi Takahashi, Naokado Ikeda, Yoshinaga Kajimoto, Yuichiro Hagiya, Shun-ichiro Ogura, Shin-ichi Miyatake
  • Journal Title: Pharmaceutics Volume: 3(3) Pages: 615-635
  • Peer Reviewed
• [Journal Article] Current states and future views in photodynamic therapy (2011)
  • Author(s): Yano S., Hirohara S., Obata M., Hagiya Y., Qgura S., Ikeda A., Kataoka H., Tanaka M., Joh T.
  • Journal Title: Journal of Photochemistry and Photobiology C : Photochemistry Reviews Volume: 12(1) Pages: 46-67
  • Peer Reviewed
• [Journal Article] Porphyrins in mouse urine after administration of 5-aminolevulinic acid as a potential tumor marker (2011)
  • Author(s): Ishizuka M., Hagiya Y., Mizokami Y., Honda K., Tabata K., Kamachi T., Takahashi K., Abe F., Tanaka T., Nakajima M., Ogura S., Okura I.
  • Journal Title: Photodiagnosis and Photodynamic Therapy Volume: 8(4) Pages: 328-331
  • Peer Reviewed
• [Journal Article] Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors : CPOX expression and 5-ALA-induced fluorescence (2011)
  • Author(s): Takahashi K.,Ikeda N., Nonoguchi N., Kajimoto Y., Miyatake S., Hagiya Y., Qgura S., Nakagawa H., Ishikawa T., Kuroiwa T.
  • Journal Title: Neuro-oncology Volume: 13(11) Pages: 1234-1243
  • Peer Reviewed
• [Journal Article] Transporter-Mediated Drug Interaction Strategy for 5-Aminolevulinic Acid (ALA)-Based Photodynamic Diagnosis of Malignant Brain Tumor : Molecular Design of ABCG2 Inhibitors (2011)
  • Author(s): Ishikawa T., Takahashi K, Ikeda N., Kajimoto Y., Hagiya Y., Qguira S.. Miyatake S., Kuroiwa T.
  • Journal Title: Pharmaceutics Volume: 3(3) Pages: 615-635
  • Peer Reviewed
• [Journal Article] The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver (2011)
  • Author(s): S.Ogura, K.Maruyama, Y.Hagiya, Y.Sugiyama, K.Tsuchiya, K.Takahashi, F.Abe, K.Tabata, I.Okura, M.Nakajima, T.Tanaka
  • Journal Title: BMC Research Notes Volume: 4 Pages: 66-66
  • Peer Reviewed
• [Journal Article] Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX (2011)
  • Author(s): T.Kunii, S.Ogura, M.Mie, E.Kobatake
  • Journal Title: Analyst Volume: 136 Pages: 1310-1312
  • Peer Reviewed
• [Journal Article] New development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy (2011)
  • Author(s): M.Ishizuka, F.Abe, Y.Sano, K.Takahashi, K.Inoue, M.Nakajima, T.Kohda, N.Komatsu, S.Ogura, T.Tanaka
  • Journal Title: International Immunopharmacology Volume: 11 Pages: 358-365
  • Peer Reviewed
• [Journal Article] Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. (2010)
  • Author(s): Keiichi Ohshima, Kanako Inoue, Akemi Fujiwara, Keiichi Hatakeyama, Kaori Kanto, Yuko Watanabe, Koji Muramatsu, Yorikane Fukuda, Shun-ichiro Ogura, Ken Yamaguchi, Tohru Mochizuki
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line (2010)
  • Author(s): K.Ohshima, K.Inoue, A.Fujiwara, K.Hatakeyama, K.Kanto, Y.Watanabe, K.Muramatsu, Y.Fukuda, S.Ogura, K.Yamaguchi, T.Mochizuki
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Presentation] アミノレブリン酸代謝における好気呼吸能の影響 (2012)
  • Author(s): 杉山雄太、萩谷祐一郎、林哲也、土屋京子、石塚昌宏、大倉一郎、小倉俊一郎
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス・矢上キャンパス
• [Presentation] Screening of transporters involved in porphyrin accumulation after administration of 5-aminolevulinic acid in vitro (2012)
  • Author(s): Matsumoto K., Hagiya Y., NakagawaH., Ishikawa T., Okura I., Ogura S
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス・矢上キャンパス
• [Presentation] 5-アミノレブリン酸を用いるがんの光線力学的療法感受性と膜輸送系の関連性 (2011)
  • Author(s): 遠藤良夫,小倉俊一郎,萩谷祐一郎,米村豊,石塚昌宏,井上克司,高橋究,中島元夫
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学札幌キャンパス
  • Year and Date: 2011-12-09
• [Presentation] 近赤外線を用いた光線力学治療 (2011)
  • Author(s): 渡瀬寛也,湯浅英哉,小倉俊一郎,萩谷祐一郎,高橋究,井上克司,田中徹
  • Organizer: GlycoTOKYO2011
  • Place of Presentation: 理化学研究所鈴木梅太郎記念ホール
  • Year and Date: 2011-12-09
• [Presentation] アミノレブリン酸のマウスシトクロムcオキシダーゼ活性に及ぼす影響 (2011)
  • Author(s): 杉山雄太、萩谷祐一郎、林哲也、土屋京子、石塚昌宏、大倉一郎、小倉俊一郎
  • Organizer: 第1回ポルフィリン-ALA学会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2011-05-07
• [Presentation] アミノレブリン酸を用いたポルフィリン蓄積に関わるトランスポーターの探索 (2011)
  • Author(s): 松本健太郎、萩谷祐一郎、中川大、大倉一郎、小倉俊一郎
  • Organizer: 第1回ポルフィリン-ALA学会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2011-05-07
• [Presentation] アミノレブリン酸(5-ALA)による悪性脳腫瘍の蛍光強度とその調節因子について (2011)
  • Author(s): 高橋賢吉、池田直廉、野々口直助、梶本宣永、宮武伸一、萩谷祐一郎、小倉俊一郎、中川大、石川智久、黒岩敏彦
  • Organizer: 第1回ポルフィリン-ALA学会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2011-05-07
• [Presentation] ALAとランタニドナノ粒子を併用した近赤外線力学治療法の開発 (2011)
  • Author(s): 湯浅英哉、渡瀬寛也、小倉俊一郎、萩谷祐一郎、高橋究、井上克司、田中徹
  • Organizer: 第1回ポルフィリン-ALA学会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2011-05-07
• [Presentation] Screening of transporters in volved inporphyrin accumulation after administration of 5-aminolevulinic acid in vitro (2011)
  • Author(s): Matsumoto K., Hagiya Y., Nakagawa H., Ishikawa T., Okura I., Ogura S
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] The Effect of 5-Aminolevulinic Acid on Cytochrome c oxidase Activity (2011)
  • Author(s): 杉山雄太、萩谷祐一郎、林哲也、土屋京子、石塚昌宏、大倉一郎、小倉俊一郎
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Molecular fluorescence imaging to assist neurosurgery of malignant brain tumors in humans : from bench to bedside (2011)
  • Author(s): Ishikawa T., Takahashi K., Ikeda N., Kajimoto Y., Hagiya Y., Ogura S., Miyatake S., and Kuroiwa T
  • Organizer: 日独がんワークショップ
  • Place of Presentation: グランドプリンスホテル広島
• [Presentation] Pivotal Role of Peptide Transporter PEPT1 and ATP-Binding Cassette(ABC) Transporter ABCG2 in 5-Aminolevulinic Acid(ALA)-Based Photodynamic Sensitization of Cancer cells in Vitro (2011)
  • Author(s): 萩谷祐一郎、遠藤良夫、米村豊、高橋究、石塚昌宏、安部史紀、田中徹、大倉一郎、中島元夫、石川智久、小倉俊一郎
  • Organizer: 平成23年度がん若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科
• [Presentation] アミノレブリン酸を用いたポルフィリン蓄積に関わるトランスポーターの探索 (2011)
  • Author(s): Matsumoto K., Hagiya Y., Nakagawa H., Ishikawa T., Ogura S
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 5-アミノレブリン酸を用いた光線力学療法におけるPEPT1およびABCG2の役割 (2011)
  • Author(s): Hagiya Y., Endo Y., Yonemura Y., Takahashi K., Ishizuka M., Abe F., Nakajima M., Ishikawa T., Ogura S
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 5-アミノレブリン酸を用いるがんの光線力学療法における感受性規定因子としての膜輸送系の関与 (2011)
  • Author(s): 遠藤良夫、小倉俊一郎、萩谷祐一郎、米村豊、石塚昌宏、井上克司、高橋究、中島元夫、木村仁
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] アミノレブリン酸のマウスシトクロムcオキシダーゼ活性に及ぼす影響 (2011)
  • Author(s): 杉山雄太、萩谷祐一郎、林哲也、土屋京子、石塚昌宏、大倉一郎、小倉俊一郎
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Role of membrane transporters in determining ALA-PDT sensitivity in human cancer cells (2011)
  • Author(s): Endo Y., Ogura S., Hagiya Y., Yonemura Y., Ishizuka M., Tanaka T., Inoue K., Takahashi K., Nakajima M
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂
• [Presentation] Role of membrane transporters in determining ALA-PDT sensitivity in human cancer cells (2011)
  • Author(s): Endo Y., Qgura S.、 Hagiya Y., Yonemura Y., Ishizuka M., Tanaka T., Inoue K., Takahashi K., Nakajima M.
  • Organizer: 日本分子生物学会第11回春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(金沢市昭和町20-1)
• [Presentation] 5-アミノレブリン酸を用いた光線力学療法におけるPEPT1およびABCG2の役割 (2011)
  • Author(s): Hagiya Y., Endo Y., Yonemura Y., Takahashi K., Ishizuka M., Abe F., Nakajima M., Ishikawa T., Qgura S.
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] アミノレブリン酸を用いたポルフィリン蓄積に関わるトランスポーターの探索 (2011)
  • Author(s): Matsumoto K., Hagiya Y., Nakagawa H., Ishikawa T., Ogura S.
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Pivotal Role of Peptide Transporter PEPT1 and ATP-Binding Cassette (ABC) Transporter ABCG2 in 5-Aminolevulinic Acid (ALA)-Based Photodynamic Sensitization of Cancer cells in Vitro (2011)
  • Author(s): 萩谷祐一郎、遠藤良夫、米村豊、高橋究、石塚昌宏、安部史紀、田中徹、大倉一郎、中島元夫、石川智久、小倉俊一郎
  • Organizer: 平成23年度がん若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科
• [Presentation] Screening of transporters involved in porphyrin accumulation after administration of 5-aminolevulinic acid in vitro (2011)
  • Author(s): Matsumoto K., Hagiya Y., Nakagawa H., Ishikawa T., Okura I., Qgura s.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 5-アミノレブリン酸を用いるがんの光線力学的療法感受性と膜輸送系の関連性 (2011)
  • Author(s): 遠藤良夫, 小倉俊一郎, 萩谷祐一郎, 米村豊, 石塚昌宏, 井上克司, 高橋究, 中島元夫
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡
• [Presentation] アミノレブリン酸を用いたポルフィリン蓄積に関わるトランスポーターの探索 (2011)
  • Author(s): 松本健太郎・萩谷祐一郎・大倉一郎・小倉俊一郎
  • Organizer: 日本化学会第91春季年会(2011)
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] アミノレブリン酸投与によるマウスシトクロムcオキシダーゼ活性への影響 (2011)
  • Author(s): 杉山雄太・萩谷祐一郎・林哲也・土屋京子・石塚昌弘・田中徹・大倉一郎・小倉俊一郎
  • Organizer: 日本化学会第91春季年会(2011)
  • Place of Presentation: 神奈川大学横浜キャンパス
• [Presentation] アミノレブリン酸投与における腫瘍特異的ポルフィリン蓄積機構の解明 (2010)
  • Author(s): 萩谷祐一郎、遠藤良夫、小倉俊一郎、大倉一郎
  • Organizer: 第37回ポルフィリン研究会学術集会
  • Place of Presentation: 東京工業大学,すずかけ台キャンパス
  • Year and Date: 2010-04-17
• [Presentation] アミノレブリン酸投与における腫瘍特異的ポルフィリン蓄積機構の解明 (2010)
  • Author(s): 萩谷祐一郎、遠藤良夫、小倉俊一郎、大倉一郎
  • Organizer: 第37回ポルフィリン研究会学術集会
  • Place of Presentation: 東京工業大学、すずかけ台キャンパス
  • Year and Date: 2010-04-17
• [Presentation] Tumor specific porphyrin accumulation after administration of 5-Aminolevulinic acid (2010)
  • Author(s): Y. Hagiya, Y. Endo, K. Inoue, K. Takahashi, S. Ogura, I. Okura
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
  • Place of Presentation: Hawaii convention center, Hawaii
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): S. Ogura, K. Tabata, T. Kamachi, I. Okura
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
  • Place of Presentation: Hawaii convention center, Hawaii
• [Presentation] Role of membrane transporters in determining ALA-PDT sensitivity in human cancer cells (2010)
  • Author(s): Y. Endo, S. Ogura, Y. Hagiya, I. Okura, Y. Yonemura, M. Ishizuka, T. Tanaka, K. Inoue, K. Takahashi, M. Nakajima
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Tumor specific porphyrin accumulation after administration of 5-Aminolevulinic acid (2010)
  • Author(s): 萩谷祐一郎、遠藤良夫、小倉俊一郎、大倉一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Tumor specific porphyrin accumulation after administration of 5-Aminolevulinic acid (2010)
  • Author(s): 萩谷祐一郎、遠藤良夫、小倉俊一郎、大倉一郎
  • Organizer: 平成22年度がん若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科
• [Presentation] アミノレブリン酸投与における腫瘍特異的ポルフィリン蓄積機構の解明 (2010)
  • Author(s): 萩谷祐一郎、遠藤良夫、小倉俊一郎、大倉一郎
  • Organizer: 第5回トランスポーター研究会年会
  • Place of Presentation: 東京医科大学病院
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): S. Ogura, K. Tabata, T. Kamachi, I. Okura
  • Organizer: The 17^<th> International SPACC Synposium
  • Place of Presentation: 鹿児島大学
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): S. Ogura, K. Tabata, T. Kamachi, I. Okura
  • Organizer: International Symposium on Advanced Biological Engineering
  • Place of Presentation: 精華大学、北京、中国
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): Shun-ichiro Ogura
  • Organizer: HIT International Symposium 2010
  • Place of Presentation: Hanyang University, Ansan, Korea
• [Presentation] アミノレブリン酸投与における腫瘍特異的ポルフィリン蓄積機構の解明 (2010)
  • Author(s): 萩谷祐一郎、遠藤良夫、小倉俊一郎、大倉一郎
  • Organizer: The 5th Annual Meeting of the Japan Transporter Research Association第5回トランスポーター研究会年会
  • Place of Presentation: 東京医科大学病院 本館6階臨床講堂
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): S.Ogura, K.Tabata, T.Kamachi, I.Okura
  • Organizer: 2010 International Symposium on Advanced Biological Engineering
  • Place of Presentation: 精華大学、北京、中国
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): S.Ogura, K.Tabata, T.Kamachi, I.Okura
  • Organizer: The 17^<th> International SPACC Symposium
  • Place of Presentation: 鹿児島大学
• [Presentation] Analysis of porphyrins in mouse plasma/urine after administration of 5-aminolevulinic acid as a potential tumor marker (2010)
  • Author(s): S.Ogura, K.Tabata, T.Kamachi, I.Okura
  • Organizer: 2010環太平洋国際化学会議The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • Place of Presentation: Hawaii convention center, Hawaii
• [Presentation] Tumor specific porphyrin accumulation after administration of 5-Aminolevulinic acid (2010)
  • Author(s): Y.Hagiya, Y.Endo, K.Inoue, K.Takahashi, S.Ogura, I.Okura
  • Organizer: 2010環太平洋国際化学会議The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • Place of Presentation: Hawaii convention center, Hawaii
• [Remarks] 新聞報道「がん」尿・血光らせ確認日刊工業新聞2011年2月16日日刊工業新聞社新聞報道老化防止作用アミノ酸ALA日刊工業新聞2011年6月28日新聞報道蛍光で光らない原因解明日刊工業新聞2011年10月5日新聞報道がん、ALAで早期発見化学工業日報2012年1月11日新聞報道ホームページ
  • URL: http://www.ogura.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.fcrc.titech.ac.jp/docs/ogura_tabata.pdf
• [Remarks]
  • URL: http://www.ogura.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.fcrc.titech.ac.jp/docs/ogura_tabata.pdf
• [Patent(Industrial Property Rights)] 光線力学的診断剤、及び、フォトブリーチング防止剤 (2012)
  • Inventor(s): 石塚昌宏・田中徹・小倉俊一郎・石井琢也
  • Industrial Property Rights Holder: SBIアラプロモ株式会社・国立大学法人東京工業大学
  • Acquisition Date: 2012-01-26
• [Patent(Industrial Property Rights)] アミノ糖連結抗がん性貴金属錯体 (2012)
  • Inventor(s): 矢野重信・柴原隆志・小倉俊一郎
  • Industrial Property Rights Holder: 国立大学法人奈良先端科学技術大学院大学
  • Acquisition Date: 2012-01-30
• [Patent(Industrial Property Rights)] 光線力学的診断剤、及び、フォトブリーチング防止剤 (2012)
  • Inventor(s): 石塚昌宏・田中徹・小倉俊一郎・石井琢也
  • Industrial Property Rights Holder: SBIアラプロモ株式会社・国立大学法人東京工業大学
  • Industrial Property Number: 2012-014135
  • Filing Date: 2012-01-26
• [Patent(Industrial Property Rights)] 赤外域光による光線力学的治療又は診断剤 (2011)
  • Inventor(s): 湯浅英哉・小倉俊一郎・高橋究・井上克司・田中徹
  • Industrial Property Rights Holder: SBIアラプロモ株式会社・国立大学法人東京工業大学
  • Acquisition Date: 2011-05-06
• [Patent(Industrial Property Rights)] 赤外域光による光線力学的治療又は診断剤 (2011)
  • Inventor(s): 湯浅英哉・小倉俊一郎・高橋究・井上克司・田中徹
  • Industrial Property Rights Holder: SBIアラプロモ株式会社・国立大学法人東京工業大学
  • Industrial Property Number: 2011-103816
  • Filing Date: 2011-05-06