| Project/Area Number |
22700912
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 分子標記治療 / ヒト悪性中皮腫 / 悪性中皮腫 / Notch シグナル / Delta-like 4 / SCID マウス / 細胞周期 / アポトーシス / Notchシグナル / SCIDマウス |
|---|
| Research Abstract |
In vitro, Delta-like 4-selective neutralizing antibody treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines, which was accompanied by an increase in phosphor-p53 levels. These effects partly involved induction of growth arrest to MM cells. In vivo, treatments with Delta-like 4-selective neutralizing antibody andγ-secretase inhibitor (an inhibition of Notch signaling)not significantly decreased the growth rate of MM. Finally, Delta-like 4-selective neutralizing antibody treatment also not significantly extended survival interval in an implant animal model of MM.
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