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Approach for prevention of metastasis of small cell lung cancer by targeting a specific splicing isoform of CADM1

Research Project

Project/Area Number 22700914
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Clinical oncology
Research InstitutionThe University of Tokyo

Principal Investigator

IWAI Miwako  東京大学, 医科学研究所, 技術専門職員 (50396884)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords小細胞肺癌・細胞接着因子・CADM1 / スプライシングバリアント・癌転移 / 小細胞 / 細胞接着分子 / CADM1 / スプライシング・バリアント / 癌転移 / 小細胞肺癌
Research Abstract

Small cell lung cancer(SCLC) is one of the most malignant cancers that metastasize to the distal organs even in its early stages. We examined the molecular mechanism underlying the malignant growth and metastasis of SCLC to identify candidate molecules targeting SCLC. The exogenous expression of CADM1 enhanced tumorigenicity of SCLC cells in nude mice, suggesting that the expression of CADM1 promotes malignant growth and metastasis of SCLC. Moreover, we found that PI3K and its downstream molecules may play roles in the malignant signaling mediated by CADM1 in SCLC.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012

    • Author(s)
      Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Masuda T, Tsuda H, Kanai Y, Onizuka M, Sato Y, and Murakami Y
    • Journal Title

      Cancer Science

      Volume: (掲載確定)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of tumor suppressors, CADM1 and 4. IB, in invasive lesions of primary breast cancer2012

    • Author(s)
      Takahashl Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y
    • Journal Title

      Breast Cancer

      Volume: (掲載確定) Issue: 3 Pages: 242-252

    • DOI

      10.1007/s12282-011-0272-7

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012

    • Author(s)
      Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, 0nizuka M, Sato Y, Murakami Y
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 6 Pages: 1051-1057

    • DOI

      10.1111/j.1349-7006.2012.02277.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells2011

    • Author(s)
      Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y
    • Journal Title

      Genes to Cells

      Volume: 16 Issue: 7 Pages: 791-802

    • DOI

      10.1111/j.1365-2443.2011.01525.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer2011

    • Author(s)
      高橋由佳
    • Journal Title

      Breast Cancer

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells2011

    • Author(s)
      伊東剛
    • Journal Title

      Genes to Cells

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 乳がんの進展、再発に関わる細胞接着因子CADM1、並びに新規分子標的の解析2011

    • Author(s)
      村上善則、高橋由佳、岩井美和子、荒川敦、伊東剛、櫻井美佳、伊藤彰彦、後藤明輝、伊東紀子、江見充、齋藤光江、霞富士雄
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膀胱癌における細胞接着分子CADM1、およびCADM4の異常2011

    • Author(s)
      川合剛人,後藤明輝、岩井美和子、永田政義、森川鉄平、久米春喜、深山正久、本間之夫、村上善則
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Dual roles of a cell adhesion molecule, CADM1/TSLC, in oncogenesis2011

    • Author(s)
      村上善則、永田政義、櫻井美佳、川合剛人、坪井裕見、岩井美和子、増田真里、後藤明輝
    • Organizer
      The 3rd CREST-SBM International Conference : Mathematical Methods in Cancer Cell Biology
    • Place of Presentation
      広島大学
    • Year and Date
      2011-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞接着分子CADM1の小細胞肺癌における特異的スプライシングバリアントの同定2010

    • Author(s)
      菊池慎二
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膀胱がんにおけるCADM1およびCADM4の異常2010

    • Author(s)
      川合剛人
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス胚性がん細胞P19のレチノイン酸誘導性神経分化におけるCADM1遺伝子の機能および転写誘導機構の解析2010

    • Author(s)
      伊東剛
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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