Approach for prevention of metastasis of small cell lung cancer by targeting a specific splicing isoform of CADM1
Project/Area Number |
22700914
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Clinical oncology
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Research Institution | The University of Tokyo |
Principal Investigator |
IWAI Miwako 東京大学, 医科学研究所, 技術専門職員 (50396884)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 小細胞肺癌・細胞接着因子・CADM1 / スプライシングバリアント・癌転移 / 小細胞 / 細胞接着分子 / CADM1 / スプライシング・バリアント / 癌転移 / 小細胞肺癌 |
Research Abstract |
Small cell lung cancer(SCLC) is one of the most malignant cancers that metastasize to the distal organs even in its early stages. We examined the molecular mechanism underlying the malignant growth and metastasis of SCLC to identify candidate molecules targeting SCLC. The exogenous expression of CADM1 enhanced tumorigenicity of SCLC cells in nude mice, suggesting that the expression of CADM1 promotes malignant growth and metastasis of SCLC. Moreover, we found that PI3K and its downstream molecules may play roles in the malignant signaling mediated by CADM1 in SCLC.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
Author(s)
Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Masuda T, Tsuda H, Kanai Y, Onizuka M, Sato Y, and Murakami Y
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Journal Title
Cancer Science
Volume: (掲載確定)
Related Report
Peer Reviewed
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[Journal Article] Aberrant expression of tumor suppressors, CADM1 and 4. IB, in invasive lesions of primary breast cancer2012
Author(s)
Takahashl Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y
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Journal Title
Breast Cancer
Volume: (掲載確定)
Issue: 3
Pages: 242-252
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
Author(s)
Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, 0nizuka M, Sato Y, Murakami Y
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Journal Title
Cancer Science
Volume: 103
Issue: 6
Pages: 1051-1057
DOI
Related Report
Peer Reviewed
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