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Construction of anti-cancer treatment strategy targeting for regulatory mechanism of glucose metabolism

Research Project

Project/Area Number 22700921
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Clinical oncology
Research InstitutionKochi University

Principal Investigator

TAGUCHI Takafumi  高知大学, 教育研究部・医療学系, 助教 (40437710)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords癌治療 / 糖代謝 / SGLT / 内分泌療法
Research Abstract

The epidermal growth factor receptor(EGFR) facilitates glucose transport into cells by associating with and stabilizing a sodium/ glucose cotransporter-1(SGLT-1). In the present study, we have evaluated the effects of Kinase inhibitor : AG1478 and SGLT-1 inhibitor : Phlorizin. We confirmed an expression of SGLT homologs, EGFR, and other key genes for glucose metabolism in ACC cells. In APOPercentage Apoptosis Assay, AG1478 alone induced concentration-dependent tumor cell death, whereas Phlorizin alone has no effect. The combination of AG1478 and Phlorizin exerted the additive inhibitory effect of ACC cell growth. PCR-array Gene Expression Profiling suggested involvement of some gene associated with glucose metabolism such as PPAR associated genes, SNAP25, IFN-γand insulin receptor in this additive inhibitory mechanism. These results demonstrated that the combined use of the EGFR and SGLT-1 antagonists to interfere with glucose metabolism of tumor cells can potentially be effective in the inhibition of ACC cell growth.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2010 Other

All Presentation (2 results)

  • [Presentation] The interactive analysis of EGFR and Na+/glucose transporter 1 (SGLT-1) inhibitors on Adrenocortical tumor cells.2010

    • Author(s)
      Takafumi Taguchi
    • Organizer
      The Endocrine Society 92th annual meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fumio Otsuka, Yoshio Terada. The interactive analysis of EGFR and Na+/ glucose transporter 1(SGLT-1) inhibitors on Adrenocortical tumor cells

    • Author(s)
      Takafumi Taguchi, Yasumasa Iwasaki, Mitsuru Nishiyama, Makoto Tsugita, Yoshinori Taniguchi, Mizuho Okazaki, Shuichi Nakayama, Toshihiro Takao
    • Organizer
      The Endocrine Society 92th annual meeting
    • Place of Presentation
      San Diego
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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