Mechanisms of resistance to EGFR tyrosine kinase inhibitors involving HER-family ligands
| Project/Area Number |
22700922
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺がん / 耐性化 / EGFRリガンド |
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| Research Abstract |
To investigate novel mechanisms of resistance to EGFR-TKI in lung cancer, we examined expression levels of HER-family ligands and phosphorylation status of HER-family receptors in EGFR-TKI primary and acquired resistant NSCLC cell lines. HER3 and HER4 binding ligands were highly expressed in primary resistant cell lines. Phosphorylation status of HER4 and its downstream STAT5 were increased in acquired resistant cell lines.
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Report
(3 results)
Research Products
(1 results)
