Mechanisms of resistance to EGFR tyrosine kinase inhibitors involving HER-family ligands

Research Project

Project/Area Number	22700922
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Clinical oncology
Research Institution	Saga University
Principal Investigator	IWANAGA Kentaro 佐賀大学, 医学部, 客員研究員 (60380755)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	肺がん / 耐性化 / EGFRリガンド
Research Abstract	To investigate novel mechanisms of resistance to EGFR-TKI in lung cancer, we examined expression levels of HER-family ligands and phosphorylation status of HER-family receptors in EGFR-TKI primary and acquired resistant NSCLC cell lines. HER3 and HER4 binding ligands were highly expressed in primary resistant cell lines. Phosphorylation status of HER4 and its downstream STAT5 were increased in acquired resistant cell lines.

Report

(3 results)