Development of zinc protoporphyrin micelles for cancer photodymanic therapy with xenon light
| Project/Area Number |
22700927
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Sojo University |
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Principal Investigator |
FANG Jun 崇城大学, 薬学部, 准教授 (20412736)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ドラッグデリバリー / 光化学療法 |
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| Research Abstract |
In this study, by comparing the physiochemical characteristics, stability as well as in vivo pharmacokinetics of different ZnPP micelles, we found that HPMA-ZnPP, with the particle size of about 80 nm, showed good stability in circulation, resulting in prolonged plasma half-life as well as tumor-selective accumulation (EPR effect). We thus selected HPMA-ZnPP for further development. In vitro studies using Hela cells exhibited a strong cytotoxicity of HPMA-ZnPP upon light irradiation. In vivo experiments showed an HPMA-ZnPP dose-dependent and irradiation dependent (intensity and duration) suppression of tumor growth. Moreover, the tumor-selective accumulation of HPMA-ZnPP was clearly detected in an in vivo imaging system. Token together, these findings strongly suggest the potential of HPMA-ZnPP as a new PDT drug for cancer, at the same time with tumor-detecting potency.
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Report
(4 results)
Research Products
(30 results)
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[Presentation] Tumor targeted imaging and photodynamic therapy by HPMA-polymer conjugated Zn-protophyrin micelle.2012
Author(s)
Fang J, Nakamura H, Qin H, Subr V, Hitaka Y, Ulbrich K, Maeda H.
Organizer
71thAnnual Meeting of the Japanese Cancer Association.
Place of Presentation
Sapporo, Japan 1247815KA003 Nakamura H, Liao L, Subr V, Hitaka Y, Tsukigawa K, Fang J, Ulbrich K, Maeda H.
Related Report
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