Development of PI3K pathway activation status and its application for predicting therapeutic efficacies of PI3-kinase inhibitors
| Project/Area Number |
22700929
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | 公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010) |
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Principal Investigator |
DAN Shingo 公益財団法人がん研究会, がん化学療法センター分子薬理部, 主任研究員 (70332202)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子標的治療 / 癌 / 抗がん剤 / PI3K / データベース / バイオマーカー |
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| Research Abstract |
To explore diagnostic biomarkers for predicting the efficacy of PI3K inhibitors including ZSTK474 that we developed previously, we examined the pathway activation status and the efficacy of PI3K inhibitors in a panel of 39 human cancer cell lines(JFCR39), and constructed an integrated database(DB). Using this DB, we found phospho-Akt and KRAS/BRAF mutation prominently correlated with the efficacy and the inefficacy of PI3K inhibitors, respectively. These correlations were confirmed in human tumor xenografts in vivo, suggesting that they could serve as predictive biomarkers in future clinical trials.
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo2012
Author(s)
Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A, Yamori T
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Journal Title
Eur J Cancer
Volume: 48(6)
Pages: 936-943
Related Report
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[Journal Article] AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy2012
Author(s)
Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T
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Journal Title
J Biol Chem
Volume: 287(6)
Issue: 6
Pages: 3885-3897
DOI
Related Report
Peer Reviewed
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[Journal Article] Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo2011
Author(s)
Anzai K, Sekine-Suzuki E, Ueno M, Okamura M, Yoshimi H, Dan S, Yaguchi S, Enami J, Yamori T, Okayasu R
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Journal Title
Cancer Sci
Volume: 102(6)
Pages: 1176-1180
NAID
Related Report
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[Journal Article] Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo.2011
Author(s)
Anzai K, Sekine-Suzuki E, Ueno M, Okamura M, Yoshimi H, Dan S, Yaguchi SI, Enami J, Yamori T, Okayasu R.
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Journal Title
Cancer Sci
Volume: (In press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status : in silico and biological evaluations2010
Author(s)
Dan S, Okamura M, Seki M, Yamazaki K, Sugita H, Okui M, Mukai Y, Nishimura H, Asaka R, Nomura K, Ishikawa Y, Yamori T
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Journal Title
Cancer Res
Volume: 70(12)
Pages: 4982-4994
Related Report
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[Journal Article] Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status : in silico and biological evaluations.2010
Author(s)
Dan S, Okamura M, Seki M, Yamazaki K, Sugita H, Okui M, Mukai Y, Nishimura H, Asaka R, Nomura K, Ishikawa Y, Yamori T.
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Journal Title
Cancer Res.
Volume: 70(12)
Pages: 4982-94
Related Report
Peer Reviewed
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