• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Diet, genes, and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

Research Project

Project/Area Number 22700934
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cancer epidemiology and prevention
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

IWASAKI Motoki  独立行政法人国立がん研究センター, がん予防・検診研究センター, 室長 (60392338)

Co-Investigator(Renkei-kenkyūsha) HAMADA Gerson shigueaki  Nikkei Disease Prevention Center, Director
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords遺伝子環境交互作用 / 日系移民 / 乳がん / 環境要因 / 遺伝要因 / 交互作用 / 症例対照研究
Research Abstract

We examined the association between green tea, calcium, vitamin D intake and the risk of breast cancer in case-control studies in Nagano and Sao Paulo. We further investigated gene-environment interaction using genetic polymorphisms related to these dietary factors. No significant association was found between green tea consumption and breast cancer risk and no significant interaction was observed by potential genetic effect modifiers. An inverse association was suggested between calcium and vitamin D intake, and breast cancer risk. We have investigated gene-environment interaction using genetic polymorphisms related to vitamin D receptor gene and blood level of vitamin D.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (12 results)

  • [Journal Article] Genome-wide association study in East asians identifies novel susceptibility Loci for breast cancer2012

    • Author(s)
      Long J, Iwasaki M,(52人中20番目)
    • Journal Title

      PLoS Genet

      Volume: 8 Pages: 1002532-1002532

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study in East asians identifies novel susceptibility Loci for breast cancer2012

    • Author(s)
      Long J, et al
    • Journal Title

      PLoS Genet

      Volume: 8 Issue: 2 Pages: e1002532-e1002532

    • DOI

      10.1371/journal.pgen.1002532

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians2011

    • Author(s)
      Iwasaki M, Hamada GS, et al.(13人中1番目)
    • Journal Title

      BMC Med

      Volume: 9 Pages: 16-16

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians2011

    • Author(s)
      Iwasaki M, Hamada GS, et al.(14人中1番目)
    • Journal Title

      Breast Cancer Res Treat

      Volume: 126 Pages: 497-505

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for breast cancer : epidemiological evidence from Japanese studies2011

    • Author(s)
      Iwasaki M, Tsugane S.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 1607-14

    • NAID

      10030242663

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies breast cancer risk variant at 10q21.2 : results from the Asia Breast Cancer Consortium2011

    • Author(s)
      Cai Q, Iwasaki M,(54人中16番目)
    • Journal Title

      Hum Mol Genet

      Volume: 20 Pages: 4991-9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry2011

    • Author(s)
      Cai Q, Iwasaki M,(46人中15番目)
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 1344-55

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians2011

    • Author(s)
      Iwasaki M, et al
    • Journal Title

      BMC Med

      Volume: 9 Issue: 1 Pages: 16-16

    • DOI

      10.1186/1741-7015-9-16

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication and Functional Genomic Analyses of the Breast cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry.2011

    • Author(s)
      Cai Q, et al.
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 1344-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Jaanese, Japanese Brazilians, and non-Japanese Brazilians.2011

    • Author(s)
      Iwasaki M, et al.
    • Journal Title

      Breast Cancer Res Treat

      Volume: 126 Pages: 497-505

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Green tea drinking and subsequent risk of breast cancer in a population to based cohort of Japanese women2010

    • Author(s)
      Iwasaki M,(8人中1番目)
    • Journal Title

      Breast Cancer Res

      Volume: 12 Pages: 88-88

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a functional genetic variant at 16q12.1 for breast cancer risk : results from the Asia Breast Cancer Consortium2010

    • Author(s)
      Long J, Iwasaki M,(41人中28番目)
    • Journal Title

      PLoS Genet

      Volume: 6 Pages: 1001002-1001002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women : a nested case-control study2010

    • Author(s)
      Iwasaki M, et al.(9人中1番目)
    • Journal Title

      Breast Cancer Res Treat

      Volume: 124 Pages: 827-34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians2010

    • Author(s)
      Iwasaki M, Hamada GS, et al.(16人中1番目)
    • Journal Title

      Nutr Cancer

      Volume: 62 Pages: 466-75

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Green tea drinking subsequent risk of breast cancer in a population to based cohort of Japanese women.2010

    • Author(s)
      Iwasaki M, et al.
    • Journal Title

      Breast Cancer Res.

      Volume: 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a functional genetic variant at 16q12.1 for breast cancer risk : results from the Asia Breast Cancer Consortium.2010

    • Author(s)
      Long J, et al.
    • Journal Title

      PLoS Genet.

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women : a nested case-control study.2010

    • Author(s)
      Iwasaki M, et al.
    • Journal Title

      Breast Cancer Res Treat.

      Volume: 124 Pages: 827-34

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes,and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.2010

    • Author(s)
      Iwasaki M, et al.
    • Journal Title

      Nutr Cancer

      Volume: 62 Pages: 466-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 緑茶摂取と乳がん罹患との関連:多目的コホート研究より2011

    • Author(s)
      岩崎基, 他
    • Organizer
      第21回日本疫学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 白血球由来DNAのグローバルなメチル化レベルと葉酸代謝に関わる食事・遺伝的要因の関連2011

    • Author(s)
      小野弘恵、岩崎基, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 余暇運動と乳がん罹患ブラジル症例対照研究2011

    • Author(s)
      鈴木礼子、岩崎基, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians2011

    • Author(s)
      Iwasaki M, Hamada GS, et al.
    • Organizer
      XIX IEA World Congress of Epidemiology
    • Place of Presentation
      Edinburgh International Conference Centre, Edinburgh, Scotland
    • Related Report
      2011 Final Research Report
  • [Presentation] 緑茶摂取と乳がん罹患との関連:多目的コホート研究より2011

    • Author(s)
      岩崎基, 他
    • Organizer
      第21回日本疫学会学術総会
    • Place of Presentation
      札幌、かでる2.7北海道立道民活動センター
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians2011

    • Author(s)
      Iwasaki M, et al
    • Organizer
      XIX IEA World Congress of Epidemiology
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analytic Epidemiology for Risk Factors of Breast Cancer among Japanese.2010

    • Author(s)
      Iwasaki M
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] International Sessions : Asian trend of molecular epidemiology : Investigation of international collaboration Molecular epidemiologic studies of Japanese Brazilians : findings from breast cancer case control studies.2010

    • Author(s)
      Iwasaki M, Tsugane S.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム「乳がんなどの女性ホルモン依存性がんのリスク要因に関する疫学的・分子疫学的研究」"多目的コホート研究(JPHC研究)からのエビデンス"2010

    • Author(s)
      岩崎基
    • Organizer
      がん予防学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] International Sessions : Asian trend of molecular epidemiology : Investigation of international collaboration. Molecular epidemiologic studies of Japanese Brazilians : findings from breast cancer case-control studies2010

    • Author(s)
      Iwasaki M, et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪、大阪国際会議場、リーガロイヤルホテル大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Analytic Epidemiology for Risk Factors of Breast Cancer among Japanese2010

    • Author(s)
      Iwasaki M.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪、大阪国際会議場、リーガロイヤルホテル大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「乳がんなどの女性ホルモン依存性がんのリスク要因に関する疫学的・分子疫学的研究」"多目的コホート研究(JPHC研究)からのエビデンス"2010

    • Author(s)
      岩崎基
    • Organizer
      がん予防学術大会2010
    • Place of Presentation
      札幌(札幌、北海道大学学術交流会館)
    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi