| Project/Area Number |
22700935
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
TOYODA Takeshi 国立医薬品食品衛生研究所, 病理部, 主任研究官 (50443453)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 化学予防 / ヘリコバクター・ピロリ / Helicobacter pylori / スナネズミ / 胃癌 |
|---|
| Research Abstract |
Although eradication therapy of Helicobacter pylori(H. pylori) has been shown to be effective for the prevention of stomach cancer, the prevention method of gastric carcinogenesis after eradication remains to be developed. In this study, we investigated the inhibitory effect of aspirin on gastric cancer after eradication using H. pylori-infected Mongolian gerbil model. We confirmed that MON/Jms strain is susceptible to H. pylori and develops severe chronic gastritis. As the long-term experiment, the MON/Jms gerbils were intra-gastrically infected with H. pylori, treated with chemical carcinogen, eradication at 36th week, and fed diet containing aspirin. Further examinations are planned to examine the chemopreventive effects of aspirin on the incidence of gastric tumor after eradication.
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