Comprehensive analyses of the nucleotide excision repair (NER) molecular mechanisms
| Project/Area Number |
22710056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
OGI Tomoo 長崎大学, 医歯薬学総合研究科, 准教授 (80508317)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | DNA修復 / 放射線DNA損傷 / 突然変異 / 発がん / ヌクレオチド除去修復 |
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| Research Abstract |
Nucleotide excision repair (NER) is a versatile DNA repair system. SiRNA-screening and next generation DNA sequencing were performed to identify novel NER factors. We found that the UVSSA gene (formerly known as KIAA1530) is involved in the transcription-coupled nucleotide-excision repair (TC-NER). The UVSSA protein interacts with TC-NER machinery and facilitates ubiquitination of RNA polymerase IIo stalled at DNA damage sites.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia.2013
Author(s)
Kashiyama, K, Nakazawa, Y, Pilz, DT, Guo, C, Sasaki, K, et al.
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Journal Title
The American Journal of Human Genetics
Volume: 92
Issue: 5
Pages: 807-819
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel syndrome2012
Author(s)
*Ogi T , Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd P, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart G, Taylor M, O'Driscoll M, and Jeggo P
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Journal Title
PLoS Genetics
Volume: 8
Issue: 11
Pages: e1002945-e1002945
DOI
NAID
Related Report
Peer Reviewed
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