Study on the effect of X-irradiation to mammalian preimplantation embryo

• Project/Area Number: 22710058
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Osaka City University
• Principal Investigator: YOSHIDA Shuhei 大阪市立大学, 大学院・医学研究科, 助教 (20363997)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生物影響 / 環境 / 放射線 / 受精卵

Research Abstract

It is important to analyze the effect of X-irradiation to mammalian fertilized eggs for people hoping childbirth. We found that in X-irradiated mouse preimplantation embryo, cell division was delayed, hatching rate was decreased, Apoptosis was induced, and DNA repair factors were assembled at double strand breaks by X-irradiation.

Research Products

• [Journal Article] Study on the effect of space Radiation on mouse ES cells (2010)
  • Author(s): Yoshida K., Yoshida S., Eguchi-Kasai K., Morita T.
  • Journal Title: Biological Sciences in Space Volume: Volume 24 Pages: 11-15
  • Peer Reviewed
• [Presentation] Study on the effect of space radiation to manmmalian ES and iPS cells to their development (2010)
  • Author(s): Yoshida, K., Yoshida, S., Eguchi-kasai, K., Morita, T.
  • Organizer: 21^<st> Annual NASA space radiation Investigator's Workshop
  • Year and Date: 2010-05-17
• [Presentation] マウス万能細胞を用いた宇宙環境の影響の解析 (2010)
  • Author(s): 吉田佳世、吉田周平、笠井清美、森田隆
  • Organizer: 日本宇宙生物科学会(第24回大会)
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/molecular-genetics/
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/molecular-genetics/
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/molecular-genetics/