Contamination status of the terrestrial mammals by organohalogen metabolite

• Project/Area Number: 22710064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Ehime University
• Principal Investigator: NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センタ-, 助教 (30512686)
• Research Collaborator: TANABE Shinsuke 愛媛大学, 沿岸環境科学研究センター, 教授 (60116952)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 微量化学物質汚染評価 / 生体内動態 / 陸棲哺乳類 / 有機ハロゲン代謝物 / 環境汚染 / PCBs / PBDEs / 水酸化代謝物 / ネコ / ペット動物 / ペットフード / 水酸化PCBs / 分析法

Research Abstract

The present study elucidates the accumulation features of PCBs, PBDEs and their hydroxylated metabolites, and specific differences in metabolic capacities of different species by analyzing the blood samples of various terrestrial mammals. As the results, metabolic capacity of PCBs in terrestrial mammals was found to vary widely among species. Lower chlorinated OH-PCB congeners(3-5 Cl) were predominant in cat blood, whereas higher chlorinated OH-PCBs were found in other mammals. The dominant congeners of OH-/MeO-PBDEs were 6OH-/MeO-BDE47 and 2' OH-/MeO-BDE68 in all the terrestrial mammals, which were already reported as natural products in the marine environment. Moreover, higher accumulation of OH-PBDEs and MeO-PBDEs were found in pet cats than pet dogs, suggesting cats may be intake of these compounds from pet food such as fish. Cats exhibited higher accumulation and a specific pattern of OH-PCBs, OH-PBDEs, and MeO-PBDEs, they may be at a high risk from these metabolites.

Research Products

• [Journal Article] Organohalogen contaminants and their hydoxylated metabolites in the blood of Japanese terrestrial mammals (2011)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tashiro, Y., Tanabe, S.
  • Journal Title: Organohalogen Compounds Volume: 73 Pages: 1207-1210
  • Peer Reviewed
• [Journal Article] Organohalogen compounds and their metabolites in the blood of Japanese amberjack(Seriola quinqueradiata) and scalloped hammerhead shark(Sphyrna lewini) from Japanese coastal waters (2011)
  • Author(s): Nomiyama, K., Uchiyama, Y., Horiuchi, S., Eguchi, A., Mizukawa, H., Hirata, S. H., Shinohara, R., Tanabe, S.
  • Journal Title: Chemosphere Volume: 85 Pages: 315-321
  • Peer Reviewed
• [Journal Article] Anthropogenic and naturally occurring polybrominated phenolic compounds in the blood of cetaceans stranded along Japanese coastal waters (2011)
  • Author(s): Nomiyama, K., Eguchi, A., Mizukawa, H., Ochiai, M., Murata, S., Someya, M., Isobe, T., Yamada, T. K., Tanabe, S.
  • Journal Title: Environmental Pollution Volume: 159 Pages: 3364-3373
  • Peer Reviewed
• [Journal Article] Organohalogen Compounds and Their Metabolites in the Blood of Japanese Amberjack (Seriola quinqueradiata) and Scalloped Hammerhead Shark (Sphyrna lewini) from Japanese Coastal Waters (2011)
  • Author(s): Kei Nomiyama, Yukiko Uchiyama, Satoko Horiuchi, Akifumi Eguchi, Hazuki Mizukawa, Sawako Horai Hirata, Ryota Shinohara, Shinsuke Tanabe
  • Journal Title: Chemosphere Volume: 85 Issue: 3 Pages: 315-321
  • DOI: 10.1016/j.chemosphere.2011.06.092
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyls and their metabolites (OH-PCBs) in the blood of toothed and baleen whales stranded along Japanese coastal waters (2010)
  • Author(s): Nomiyama, K.
  • Journal Title: Environmental Science and Technology Volume: 44 Pages: 3732-3738
  • Peer Reviewed
• [Journal Article] Accumulation features of PCBs and hydroxylated metabolites in the blood of terrestrial mammals (2010)
  • Author(s): Mizukawa, H.
  • Journal Title: Organohalogen Compounds Volume: 72 Pages: 944-947
  • Peer Reviewed
• [Presentation] Organohalogen Contaminants and their hydoxylated metabolites in the blood of Japanese terrestrial mammals (2011)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tashiro, Y., Tanabe, S.
  • Organizer: 31^<st> International Symposium on Halogenated Persistent Organic Pollutants(Dioxin 2011)
  • Place of Presentation: Brussels, Belgium
• [Presentation] Organohalogen metabolites in terrestrial mammals : Does carnivorous species have potential risk by hydroxylated metabolites? (2011)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tanabe, S.
  • Organizer: The 4th Joint Forum of Environmental Sciences 2011
  • Place of Presentation: Matsuyama, Ehime
• [Presentation] Comprehensive studies on halogenated phenolic compounds in blood of terrestrial mammals from Japan (2011)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tashiro, Y., Yamamoto, M., Tanabe, S.
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本市
• [Presentation] Organohalogen Contaminants and their hydoxylated metabolites in the blood of Japanese terrestrial mammals (2011)
  • Author(s): Mizukawa, H.
  • Organizer: DIOXIN2011
  • Place of Presentation: Brussels, Belgium
• [Presentation] Organohalogen compounds and their metabolites in the blood of Japanese amberjack (Seriola quinqueradiata) and scalloped hammerhead shark (Sphyrna lewini) from Japanese coastal waters (2011)
  • Author(s): Nomiyama, K.
  • Organizer: DIOXIN2011
  • Place of Presentation: Brussels, Belgium
• [Presentation] Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in the blood of toothed and baleen whales stranded at Japanese coastal waters (2010)
  • Author(s): Nomiyama, K.
  • Organizer: 30^<th> International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2010)
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 2010-09-13
• [Presentation] Accumulation features of PCBs and hydroxylated metabolites in the blood of terrestrial mammals (2010)
  • Author(s): Mizukawa, H.
  • Organizer: 30^<th> International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2010)
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 2010-09-13
• [Presentation] Accumulation features of PCBs and hydroxylated metabolites in the blood of terrestrial mammals (2010)
  • Author(s): Mizukawa, H.
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 春日井市
  • Year and Date: 2010-06-23
• [Book] Accumulation features of organohalogen metabolites in the blood of Japanese terrestrial mammals (2012)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tashiro, Y., Yamamoto, M. and Tanabe, S.
  • Publisher: TERRAPUB, Tokyo, Japan
• [Book] Contamination status and accumulation features of organohalogen compounds in raccoon dog and masked palmcivet (2012)
  • Author(s): Yamamoto, M., Isobe, T., Hayashi, T., Yachimori, S., Nomiyama, K. and Tanabe, S.
  • Publisher: TERRAPUB, Tokyo, Japan
• [Book] Accumulation features of hydroxylated-PCBs(OH-PCBs) in the blood of pigs collected from a dumping site for municipal wastes in India (2010)
  • Author(s): Mizukawa, H., Nomiyama, K., Kunisue, T., Watanabe, M. X., Subramanian, Takahashi, S. Tanabe, S.
  • Publisher: TERRAPUB, Tokyo, Japan
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.4, Environmental Specimen Bank : Exploring Possibility of Setting-up ESBs in Developing Countries (2010)
  • Author(s): Isobe, T.
  • Total Pages: 222
  • Publisher: TERRAPUB, Tokyo, Japan
• [Remarks]
  • URL: http://ehime-u.cyber-earth.jp/g-coe2007/jp/index.aspx
• [Remarks]
  • URL: http://www.ehime-u.ac.jp/~cmes/tanabe/04_project/project_s.html