Design of Stimuli-Responsive Particles with Tunable Enzymatic Activity

• Project/Area Number: 22710097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Tohoku University
• Principal Investigator: ISHII Haruyuki 東北大学, 大学院・工学研究科, 助教 (80565820)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 中空シリカ粒子 / ベシクル / 酵素様活性 / 無機ナノ粒子 / 温度応答性ゲル / 中空シリカ / リポソーム / ナノ粒子ベシクル / ラズベリー構造 / ベシクルテンプレート法 / 形態制御 / 水相合成 / 反応pH / 静電相互作用

Research Abstract

Inorganic nanoparticles with enzyme-like activity were deposited on thermo-responsive particles that are vesicle-including hollow silica particles or polymer gel particles. Silica coating of vesicles was first examined and solution pH affected the morphology of silica shell. Gold and ceria nanoparticles were then adsorbed on the vesicles, followed by the silica coating. As-synthesized composite particles can be used as biosensors and catalysts with enzyme-like activity. Platinum nanoparticles were deposited on the poly(N-isopropylacrylamide) gel particles with in situ method and the composite particle showed catalase-like enzymatic activity.

Research Products

• [Journal Article] Anionic liposo me template synthesis of raspberry-l ike hollow silica particle under ambi ent conditions with basic catalyst (2012)
  • Author(s): Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
  • Journal Title: Colloid and Surfaces B: Biointerfaces Volume: 92 Pages: 372-376
  • DOI: 10.1016/j.colsurfb.2011.11.005
  • Peer Reviewed
• [Presentation] セリア-シリカ複合中空粒子の合成に関する研究 (2013)
  • Author(s): 伊藤早希、石井治之、長尾大輔、今野幹男
  • Organizer: 化学工学会第78年会
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-03-19
• [Presentation] ベシクルテンプレート法を利用した金ナノ粒子複合中空シリカ粒子の合成 (2013)
  • Author(s): 工藤麻美、石井治之、長尾大輔、今野幹男
  • Organizer: 化学工学会第78年会
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-03-19
• [Presentation] Novel Designs of Mesoporous Hollow SilicaParticles via Anionic Surfactant Templating Route (2013)
  • Author(s): Haruyuki Ishii, Saki Ito, Kumi Sato, Daisuke Nagao, Mikio Konno
  • Organizer: 8th International Mesostructured Materials Symposium
  • Place of Presentation: 兵庫
• [Presentation] Haruyuki Ishii, Saki Ito, Kumi Sato, Daisuke Nagao, Mikio Konno (2013)
  • Author(s): Novel Designs of Mesoporous Hollow Silica Particles via Anionic Surfactant Templating Route
  • Organizer: 8th International Mesostructured Materials Symposium
  • Place of Presentation: 淡路島、兵庫県
• [Presentation] セリア-シリカ複合中空粒子の合成に関する研究 (2013)
  • Author(s): 伊藤 早希、石井 治之、長尾 大輔、今野 幹男
  • Organizer: 化学工学会 第78年会
  • Place of Presentation: 豊中市、大阪府
• [Presentation] ベシクルテンプレート法を利用した金ナノ粒子複合中空シリカ粒子の合成 (2013)
  • Author(s): 工藤麻美、石井 治之、長尾 大輔、今野 幹男
  • Organizer: 化学工学会 第78年会
  • Place of Presentation: 豊中市、大阪府
• [Presentation] Formation of raspberry-like and smooth silica shells in vesicle-template synthesis (2012)
  • Author(s): Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
  • Organizer: IACIS2012
  • Place of Presentation: 宮城県
  • Year and Date: 2012-05-15
• [Presentation] Formation of raspberry-like and smooth silica shells in vesicle-template synthesis (2012)
  • Author(s): Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
  • Organizer: IACIS2012
  • Place of Presentation: 仙台市、宮城県
• [Presentation] リポソームを鋳型とした中空シリカ粒子のシェル形態制御に関する研究 (2011)
  • Author(s): 佐藤公美、石井治之、長尾大輔、今野幹男
  • Organizer: 化学工学会札幌大会2011
  • Place of Presentation: 北海道大学
  • Year and Date: 2011-08-25
• [Presentation] リポソームを鋳型とした中空シリカ粒子のシェル形態制御に関する研究 (2011)
  • Author(s): 佐藤公美、石井治之、長尾大輔、今野幹男
  • Organizer: 化学工学会札幌大会2011
  • Place of Presentation: 北海道
  • Year and Date: 2011-08-25
• [Presentation] Raspberry-like Hollow Silica Particles Synthesized by Using Negatively Charged Vesicles as Templates (2011)
  • Author(s): Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
  • Organizer: 10th International Confe- rence on Materials Chemistry (MC10)
  • Place of Presentation: Manchester, U.K.
  • Year and Date: 2011-07-04
• [Presentation] Raspberry-like Hollow Silica Particles Synthesized by Using Negatively Charged Vesicles as Templates (2011)
  • Author(s): Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
  • Organizer: 10^<th> International Conference on Materials Chemistry (MC10)
  • Place of Presentation: マンチェスター(U.K.)
  • Year and Date: 2011-07-04
• [Presentation] 中空シリカ粒子のリポソームテンプレート合成に及ぼすリポソーム表面特性の影響 (2011)
  • Author(s): 石井治之、佐藤公美、長尾大輔、今野幹男
  • Organizer: 化学工学会第76年会
  • Place of Presentation: 東京農工大学
  • Year and Date: 2011-03-24
• [Presentation] 中空シリカ粒子のリポソームテンプレート合成に及ぼすリポソーム表面特性の影響 (2011)
  • Author(s): 石井治之、佐藤公美、長尾大輔, 今野幹男
  • Organizer: 化学工学会第76年会
  • Place of Presentation: 東京農工大学(小金井キャンパス)
  • Year and Date: 2011-03-24
• [Presentation] アニオン性リポソームを鋳型とした中空シリカ粒子の合成 (2011)
  • Author(s): 佐藤公美、石井治之、長尾大輔、今野幹男
  • Organizer: 第13回化学工学会学生発表会(秋田大会)
  • Place of Presentation: 秋田大学
  • Year and Date: 2011-03-05
• [Presentation] アニオン性リポソームを鋳型とした中空シリカ粒子の合成 (2011)
  • Author(s): 佐藤公美、石井治之、長尾大輔, 今野幹男
  • Organizer: 第13回化学工学会学生発表会(秋田大会)
  • Place of Presentation: 秋田大学(手形キャンパス)
  • Year and Date: 2011-03-05
• [Presentation] 脂質ベシクルを鋳型とした中空シリカ粒子の合成 (2010)
  • Author(s): 石井治之、佐藤公美、長尾大輔、今野幹男
  • Organizer: 材料化学システム工学討論会2010
  • Place of Presentation: 京都大学
  • Year and Date: 2010-12-10
• [Presentation] 脂質ベシクルを鋳型とした中空シリカ粒子の合成 (2010)
  • Author(s): 石井治之、佐藤公美、長尾大輔, 今野幹男
  • Organizer: 材料化学システム工学討論会2010
  • Place of Presentation: 京都大学(桂キャンパス)
  • Year and Date: 2010-12-10
• [Presentation] A Facile Synthesis of Hollow Silica Particles in Aqueous Media by Using Negatively Charged Liposomes as Templates (2010)
  • Author(s): Haruyuki Ishii, Daisuke Nagao,Mikio Konno
  • Organizer: 8th International Sym- posium on Membrane Stress Biotechnology
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-22
• [Presentation] A Facile Synthesis of Hollow Silica Particles in Aqueous Media by Using Negatively Charged Liposomes as Templates (2010)
  • Author(s): Haruyuki Ishii, Daisuke Nagao, Mikio Konno
  • Organizer: 8th International Symposium on Membrane Stress Biotechnology
  • Place of Presentation: 大阪大学(吹田キャンパス)
  • Year and Date: 2010-09-22
• [Presentation] Anionic Liposome-Template Synthesis of Hollow Silica Particles (2010)
  • Author(s): Haruyuki Ishii,Daisuke Nagao, Mikio Konno
  • Organizer: 7th International Symposium on Engineering Science of Liposome
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-19
• [Presentation] Anionic Liposome-Template Synthesis of Hollow Silica Particles (2010)
  • Author(s): Haruyuki Ishii, Daisuke Nagao, Mikio Konno
  • Organizer: 7th International Symposium on Engineering Science of Liposome
  • Place of Presentation: 大阪大学(豊中キャンパス)
  • Year and Date: 2010-09-19
• [Remarks]
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• [Remarks] 東北大学工学研究科 今野研究室ホームページ
  • URL: http://www.che.tohoku.ac.jp/~mickey/
• [Remarks]
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• [Remarks]
  • URL: http://db.tohoku.ac.jp/whois/detail/cf725773f073e1a5795dcc875dfc1168.html
• [Remarks]
  • URL: http://www.che.tohoku.ac.jp/~mickey/index2.html
• [Remarks]
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