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Design of Stimuli-Responsive Particles with Tunable Enzymatic Activity

Research Project

Project/Area Number 22710097
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionTohoku University

Principal Investigator

ISHII Haruyuki  東北大学, 大学院・工学研究科, 助教 (80565820)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords中空シリカ粒子 / ベシクル / 酵素様活性 / 無機ナノ粒子 / 温度応答性ゲル / 中空シリカ / リポソーム / ナノ粒子ベシクル / ラズベリー構造 / ベシクルテンプレート法 / 形態制御 / 水相合成 / 反応pH / 静電相互作用
Research Abstract

Inorganic nanoparticles with enzyme-like activity were deposited on thermo-responsive particles that are vesicle-including hollow silica particles or polymer gel particles. Silica coating of vesicles was first examined and solution pH affected the morphology of silica shell. Gold and ceria nanoparticles were then adsorbed on the vesicles, followed by the silica coating. As-synthesized composite particles can be used as biosensors and catalysts with enzyme-like activity. Platinum nanoparticles were deposited on the poly(N-isopropylacrylamide) gel particles with in situ method and the composite particle showed catalase-like enzymatic activity.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2013 2012 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (22 results) Remarks (6 results)

  • [Journal Article] Anionic liposo me template synthesis of raspberry-l ike hollow silica particle under ambi ent conditions with basic catalyst2012

    • Author(s)
      Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
    • Journal Title

      Colloid and Surfaces B: Biointerfaces

      Volume: 92 Pages: 372-376

    • DOI

      10.1016/j.colsurfb.2011.11.005

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] セリア-シリカ複合中空粒子の合成に関する研究2013

    • Author(s)
      伊藤早希、石井治之、長尾大輔、今野幹男
    • Organizer
      化学工学会第78年会
    • Place of Presentation
      大阪大学
    • Year and Date
      2013-03-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ベシクルテンプレート法を利用した金ナノ粒子複合中空シリカ粒子の合成2013

    • Author(s)
      工藤麻美、石井治之、長尾大輔、今野幹男
    • Organizer
      化学工学会第78年会
    • Place of Presentation
      大阪大学
    • Year and Date
      2013-03-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel Designs of Mesoporous Hollow SilicaParticles via Anionic Surfactant Templating Route2013

    • Author(s)
      Haruyuki Ishii, Saki Ito, Kumi Sato, Daisuke Nagao, Mikio Konno
    • Organizer
      8th International Mesostructured Materials Symposium
    • Place of Presentation
      兵庫
    • Related Report
      2012 Final Research Report
  • [Presentation] Haruyuki Ishii, Saki Ito, Kumi Sato, Daisuke Nagao, Mikio Konno2013

    • Author(s)
      Novel Designs of Mesoporous Hollow Silica Particles via Anionic Surfactant Templating Route
    • Organizer
      8th International Mesostructured Materials Symposium
    • Place of Presentation
      淡路島、兵庫県
    • Related Report
      2012 Annual Research Report
  • [Presentation] セリア-シリカ複合中空粒子の合成に関する研究2013

    • Author(s)
      伊藤 早希、石井 治之、長尾 大輔、今野 幹男
    • Organizer
      化学工学会 第78年会
    • Place of Presentation
      豊中市、大阪府
    • Related Report
      2012 Annual Research Report
  • [Presentation] ベシクルテンプレート法を利用した金ナノ粒子複合中空シリカ粒子の合成2013

    • Author(s)
      工藤麻美、石井 治之、長尾 大輔、今野 幹男
    • Organizer
      化学工学会 第78年会
    • Place of Presentation
      豊中市、大阪府
    • Related Report
      2012 Annual Research Report
  • [Presentation] Formation of raspberry-like and smooth silica shells in vesicle-template synthesis2012

    • Author(s)
      Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
    • Organizer
      IACIS2012
    • Place of Presentation
      宮城県
    • Year and Date
      2012-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Formation of raspberry-like and smooth silica shells in vesicle-template synthesis2012

    • Author(s)
      Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
    • Organizer
      IACIS2012
    • Place of Presentation
      仙台市、宮城県
    • Related Report
      2012 Annual Research Report
  • [Presentation] リポソームを鋳型とした中空シリカ粒子のシェル形態制御に関する研究2011

    • Author(s)
      佐藤公美、石井治之、長尾大輔、今野幹男
    • Organizer
      化学工学会札幌大会2011
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] リポソームを鋳型とした中空シリカ粒子のシェル形態制御に関する研究2011

    • Author(s)
      佐藤公美、石井治之、長尾大輔、今野幹男
    • Organizer
      化学工学会札幌大会2011
    • Place of Presentation
      北海道
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Raspberry-like Hollow Silica Particles Synthesized by Using Negatively Charged Vesicles as Templates2011

    • Author(s)
      Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
    • Organizer
      10th International Confe- rence on Materials Chemistry (MC10)
    • Place of Presentation
      Manchester, U.K.
    • Year and Date
      2011-07-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Raspberry-like Hollow Silica Particles Synthesized by Using Negatively Charged Vesicles as Templates2011

    • Author(s)
      Haruyuki Ishii, Kumi Sato, Daisuke Nagao, Mikio Konno
    • Organizer
      10^<th> International Conference on Materials Chemistry (MC10)
    • Place of Presentation
      マンチェスター(U.K.)
    • Year and Date
      2011-07-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 中空シリカ粒子のリポソームテンプレート合成に及ぼすリポソーム表面特性の影響2011

    • Author(s)
      石井治之、佐藤公美、長尾大輔、今野幹男
    • Organizer
      化学工学会第76年会
    • Place of Presentation
      東京農工大学
    • Year and Date
      2011-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 中空シリカ粒子のリポソームテンプレート合成に及ぼすリポソーム表面特性の影響2011

    • Author(s)
      石井治之、佐藤公美、長尾大輔, 今野幹男
    • Organizer
      化学工学会第76年会
    • Place of Presentation
      東京農工大学(小金井キャンパス)
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] アニオン性リポソームを鋳型とした中空シリカ粒子の合成2011

    • Author(s)
      佐藤公美、石井治之、長尾大輔、今野幹男
    • Organizer
      第13回化学工学会学生発表会(秋田大会)
    • Place of Presentation
      秋田大学
    • Year and Date
      2011-03-05
    • Related Report
      2012 Final Research Report
  • [Presentation] アニオン性リポソームを鋳型とした中空シリカ粒子の合成2011

    • Author(s)
      佐藤公美、石井治之、長尾大輔, 今野幹男
    • Organizer
      第13回化学工学会学生発表会(秋田大会)
    • Place of Presentation
      秋田大学(手形キャンパス)
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂質ベシクルを鋳型とした中空シリカ粒子の合成2010

    • Author(s)
      石井治之、佐藤公美、長尾大輔、今野幹男
    • Organizer
      材料化学システム工学討論会2010
    • Place of Presentation
      京都大学
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂質ベシクルを鋳型とした中空シリカ粒子の合成2010

    • Author(s)
      石井治之、佐藤公美、長尾大輔, 今野幹男
    • Organizer
      材料化学システム工学討論会2010
    • Place of Presentation
      京都大学(桂キャンパス)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Facile Synthesis of Hollow Silica Particles in Aqueous Media by Using Negatively Charged Liposomes as Templates2010

    • Author(s)
      Haruyuki Ishii, Daisuke Nagao,Mikio Konno
    • Organizer
      8th International Sym- posium on Membrane Stress Biotechnology
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] A Facile Synthesis of Hollow Silica Particles in Aqueous Media by Using Negatively Charged Liposomes as Templates2010

    • Author(s)
      Haruyuki Ishii, Daisuke Nagao, Mikio Konno
    • Organizer
      8th International Symposium on Membrane Stress Biotechnology
    • Place of Presentation
      大阪大学(吹田キャンパス)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anionic Liposome-Template Synthesis of Hollow Silica Particles2010

    • Author(s)
      Haruyuki Ishii,Daisuke Nagao, Mikio Konno
    • Organizer
      7th International Symposium on Engineering Science of Liposome
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Anionic Liposome-Template Synthesis of Hollow Silica Particles2010

    • Author(s)
      Haruyuki Ishii, Daisuke Nagao, Mikio Konno
    • Organizer
      7th International Symposium on Engineering Science of Liposome
    • Place of Presentation
      大阪大学(豊中キャンパス)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.che.tohoku.ac.jp/~mickey/index2.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 東北大学工学研究科 今野研究室ホームページ

    • URL

      http://www.che.tohoku.ac.jp/~mickey/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.che.tohoku.ac.jp/~mickey/index2.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://db.tohoku.ac.jp/whois/detail/cf725773f073e1a5795dcc875dfc1168.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.che.tohoku.ac.jp/~mickey/index2.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://db.tohoku.ac.jp/whois/detail/cf725773f073ela5795dcc875dfc1168.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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