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Fundamental studies on application of carbon nanotubes to oral drug delivery for the treatment of bowl diseases

Research Project

Project/Area Number 22710112
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

NAKAMURA Maki  独立行政法人産業技術総合研究所, ナノチューブ応用研究センター, 産総研特別研究員 (00568925)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナノ材料 / 機能性材料 / カーボンナノホーン / 経口投与 / 薬物送達 / 腸疾患治療 / カーボンナノチューブ / DDS
Research Abstract

Carbon nanotubes are nanometer-sized carbon materials, which are expected to be applicable to drug carriers of drug delivery systems. In mice experiment, orally-administered carbon nanotubes were not absorbed from the gastrointestinal tract, and excreted in feces, suggesting that neither accumulation of orally-administered carbon nanotubes in body nor associated toxicity would be observed. These results indicated that carbon nanotubes could be riskless oral drug carriers in drug therapy of inflammatory bowel diseases.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Single-walled carbon nanohorns as drug carriers : adsorption of prednisolone and anti-inflammatory effects on arthritis2011

    • Author(s)
      中村真紀、田原善夫、池原譲、村上達也、土田邦博、飯島澄男、和賀巌、湯田坂雅子
    • Journal Title

      Nanotechnology

      Volume: vol.22 Pages: 465102-465102

    • URL

      http://iopscience.iop.org/0957-4484/22/46/465102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-walled carbon nanohorns as drug carriers : adsorption of prednisolone and anti-inflammatory effects on arthritis2011

    • Author(s)
      Nakamura M., Tsuchida K., 他6名
    • Journal Title

      Nanotechnology

      Volume: 22巻 Issue: 46 Pages: 465102-465102

    • DOI

      10.1088/0957-4484/22/46/465102

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] カーボンナノホーンの薬剤キャリアへの応用2011

    • Author(s)
      中村真紀、田原善夫、池原譲、村上達也、土田邦博、飯島澄男、和賀巌、湯田坂雅子
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノホーンのドラッグキャリアへの応用-プレドニゾロンの担持と関節炎への抗炎症作用2010

    • Author(s)
      中村真紀、田原善夫、村上達也、土田邦博、飯島澄男、和賀巌、湯田坂雅子
    • Organizer
      第39回フラーレン・ナノチューブ総合シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] カーボンナノホーンの薬剤キャリアへの応用

    • Author(s)
      中村真紀
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      (静岡)(震災の為、年会の開催は中止だが、発表は成立)
    • Related Report
      2010 Annual Research Report
  • [Book] カーボンナノチューブ・グラフェンハンドブック2011

    • Author(s)
      中村真紀、張民芳、湯田坂雅子
    • Publisher
      コロナ社
    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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