Project/Area Number |
22710125
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Microdevices/Nanodevices
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
FUCHIWAKI Yusuke 独立行政法人産業技術総合研究所, 健康工学研究部門, 研究員 (80468884)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | バイオチップ / 分子インプリント / LSPR / 金ナノ / インクジェット / MIP / ナノ材料 / マイクロナノデバイス / チップ / 非標識 / アルツハイマー |
Research Abstract |
We studied to develop a novel label-free biochip device for early diagnosis of Alzheimer's disease using molecularly imprinted-based artificial receptors. In order to improve the nonspecific adsorption on surface of nano-artificial receptors, the newly functional polymer, which includes both phophorylcholine and amino groups, was synthesized and accomplished to increase signal to noise ratio. Ink-jet printing technology has been included for the accurate preparation of bio-recognition interface, and got in about three times lower variations from calibration curves as compared to previous studies.
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