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Elucidation of functional diversity of heterochromatin using ChIP-seq

Research Project

Project/Area Number 22710180
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Genome biology
Research InstitutionHokkaido University

Principal Investigator

NAGAO Koji  北海道大学, 大学院・先端生命科学研究院, 助教 (60426575)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエピゲノム / ヘテロクロマチン / バイオインフォマティクス / ゲノム
Research Abstract

Heterochromatin plays an essential role for the maintenance of chromosomal integrity and the regulation of cell specific gene expression pattern. In this study, we map heterochromatin-associated proteins throughout genome using ChIP-seq(chromatin immunoprecipitation combined with high-throughput sequencing) method, and elucidate the architecture of human heterochromatin.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast2011

    • Author(s)
      Fukuura, M., Nagao, K., Obuse, C., Takahashi, T. S., Nakagawa, T., and Masukata, H.
    • Journal Title

      Mol. Biol. Cell

      Volume: 14 Pages: 2620-2633

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast2011

    • Author(s)
      Fukuura M.、 Nagao K.、 Obuse C.、 Takahashi T.S.、 Nakagawa T.、Masukata H.
    • Journal Title

      Molecular biology of the cell

      Volume: 22(14) Issue: 14 Pages: 2620-2633

    • DOI

      10.1091/mbc.e10-12-0995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation2010

    • Author(s)
      Nozawa, R. S., Nagao, K., Masuda, H. T., Iwasaki, O., Hirota, T., Nozaki, N., Kimura, H., and Obuse, C.
    • Journal Title

      Nat. Cell Biol

      Volume: 12 Pages: 719-727

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒトHP1結合タンパク質のプロテオーム解析からみえてきたHP1の新機能2010

    • Author(s)
      野澤竜介、長尾恒治、小布施力史
    • Journal Title

      実験医学

      Volume: 28 Pages: 2983-2986

    • Related Report
      2011 Final Research Report
  • [Journal Article] ヒトHP1結合タンパク質POGZは分裂前期のAurora Bキナーゼの染色体腕部での活性化に寄与する2010

    • Author(s)
      野澤竜介、長尾恒治、小布施力史
    • Journal Title

      細胞工学

      Volume: 29 Pages: 868-870

    • Related Report
      2011 Final Research Report
  • [Journal Article] Human POGZ modulates dissociation of HP1 alpha from mitotic chromosome arms through Aurora B activation.2010

    • Author(s)
      Nozawa, R.
    • Journal Title

      Nat.Cell.Biol.

      Volume: 12 Pages: 719-727

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.2010

    • Author(s)
      Takeda, K.
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107 Pages: 3540-3545

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ChIP-seq Analysis of Heterochromatin-associated Histone Modifications in Human Female Cells2012

    • Author(s)
      長尾恒治、野澤竜介、柴田幸子、木村宏、小布施力史
    • Place of Presentation
      北海道大学
    • Year and Date
      2012-02-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ChIP-seq Analysis of Heterochromatin-associated Histone Modifications in Human Female Cells2012

    • Author(s)
      長尾恒治
    • Organizer
      「哺乳類X染色体不活性化について」研究会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ChIP-seq Analysis of Heterochromatin-associated Histone Modifications in Human Female Cells2011

    • Author(s)
      長尾恒治、野澤竜介、柴田幸子、木村宏、小布施力史
    • Organizer
      BMB2011第34回日本分子細胞生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] ChIP-seq Analysis of Heterochromatin-associated Histone Modifications in Human Female Cells2011

    • Author(s)
      長尾恒治
    • Organizer
      第34回日本分子細胞生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitiative Proteomic Analysis of HP1αInteraction Network-Four Different Interaction Modes of HP1αwith Its Associated Proteins2011

    • Author(s)
      Koji Nagao, Ryu-suke Nozawa, and Chikashi Obuse
    • Organizer
      International Symposium Physicochemical Field for Genetic Activities
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2011-01-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Quantitative Proteomic Analysis of HP1 α Interaction Network-Four Different Interaction Modes of HP1 α with Its Associated Proteins.2011

    • Author(s)
      長尾恒治
    • Organizer
      International Symposium Physicochemical Field for Genetic Activities
    • Place of Presentation
      淡路市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 半定量プロテオミクスによるヒトHP1αタンパク質間相互作用ネットワークの解明-HP1は4つの異なる様式でさまざまなタンパク質と相互作用する2010

    • Author(s)
      長尾恒治、野澤竜介、小布施力史
    • Organizer
      BMB2010第33回日本分子細胞生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 判定量プロテオミクスによるヒトHP1αタンパク質間相互作用ネットワークの解明-HP1は4つの異なる様式でさまざまなタンパク質と相互作用する2010

    • Author(s)
      長尾恒治
    • Organizer
      BMB2010
    • Place of Presentation
      神戸市
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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