Database construction for transcriptional regulation in Streptomyces and Synechocystis and these applications
| Project/Area Number |
22710199
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
System genome science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAKITA Yuko 独立行政法人理化学研究所, 生命情報基盤研究部門, 研究員 (80443026)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,690,543 (Direct Cost: ¥4,377,341、Indirect Cost: ¥1,313,202)
Fiscal Year 2012: ¥1,660,543 (Direct Cost: ¥1,277,341、Indirect Cost: ¥383,202)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リファレンスデータベース / 転写制御 / 文献抽出 / 比較ゲノム / プロモータ解析 / ネットワークモチーフ解析 / データベース / Streptomyces / Synochocystis / 放線菌 / マニュアルアノテーション / 光合成細菌 / Synecocystis |
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| Research Abstract |
Recent works in bacterial transcriptional network analysis reveal that transcriptional regulations are flexible and evolve rapidly. It is therefore important to construct reference databases on transcriptional regulation of multiple model organisms. I constructed referenced databases in Streptomyces and Synechocystis with manually collected data from nearly 500 literatures. By using the collected data, I performed comparative genome analysis and network motif analysis and suggested specificity of transcriptional networks in species-specific functions, such as antibiotic synthesis of Streptomyces and photosynthesis of Synechocystis.
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Report
(4 results)
Research Products
(12 results)
