In vitro selection of non-standard cyclic peptides that regulate maturation of miRNAs
| Project/Area Number |
22710210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAYUKI Katoh 東京大学, 大学院・理学系研究科, 助教 (90567760)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ケミカルバイオロジー / マイクロRNA / 特殊ペプチド / mRNAディスプレイ / FITシステム / 遺伝暗号リプログラミング / 分子標的医薬 / ペプチド医薬 / 特殊環状ペプチド |
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| Research Abstract |
In this proect, we tried to develop non-standard cyclic peptides that can inhibit the maturation of miRNA precursor by using RaPID display method, which is a combination of genetic code reprogramming and mRNA display. So far, we have successfully obtained several cyclic peptides that have binding affinity to miR-21 precursor. Evaluations of specificity and binding affinity of the peptides are under way.
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Report
(3 results)
Research Products
(22 results)
