| Project/Area Number |
22710220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖鎖 / 分子デザイン / 合成 / ボロン酸 / 分子認識 / 低分子レセプター / 結核 / シアル酸 / 糖鎖認識 / ガン転移 / ガラクトフラノシド / 人工低分子レセプター / 光分解 / 人工レセプター |
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| Research Abstract |
Small molecules, which selectively bind to and effectively photodegrade target disease-related oligosaccharides under mild conditions, were designed and synthesized. It was found that synthesized anthraquinone(AQ)-or fullerene-boronic acid hybrids selectively bound to and photodegraded.-D-galactofuranoside, which is a sugar component of mycobacterial cell wall. In addition, it was found that photodegradation of the target oligosaccharides on the bacterial cell wall by AQ-boronic acid hybrid took place and induced significant whole-cell destruction. Furthermore, several molecules that bind to sialic acid were designed and synthesized. The results obtained from this study will contribute to the molecular design of photodegrading agents for cancer-related oligosaccharides.
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