New approach to the mechanism of long-term memory with microfluidic culturing systems
| Project/Area Number |
22710221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
HIROI Noriko 慶應義塾大学, 理工学部, 助教 (20548408)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 活性発現の分子機構 / 数理モデル / 神経分化 / マイクロ流体デバイス / コンタクトプリンティング / マイクロナノデバイス / モデル化 / バイオリアクター / 脳・神経 |
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| Research Abstract |
We developed a mathematical model representing the mechanisms of sustainable synaptogenesis, which is the basal mechanism of long-term memory. The model predicted the essential mechanism of long-term memory is to keep the context of the signal transduction controlled by the time intervals of the external stimuli. To evaluate the prediction, we developed a microfluidic device, a control board and a set of software to control electromagnetic valves.
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Report
(3 results)
Research Products
(3 results)
