| Project/Area Number |
22710223
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
|
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| Research Institution | Yokohama City University (2011)
Keio University (2010) |
|---|
Principal Investigator |
ISHIKAWA Yuichi 横浜市立大学, 国際総合科学部, 助教 (40348826)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 構造活性相関 / 低酸素 / ステロイド / 抗がん剤 |
|---|
| Research Abstract |
Synthesis of strongylophorine analogues, inhibitors of hypoxia-inducible factor-1(HIF-1) transcriptional pathway, was attempted. Considering the structure of strongylophorines, synthesis of analogue possessing a distinctive lactone structure commenced with cholesterol, easily available steroid compound. The efforts of functionalization against cholesterol derivatives provided the desired analogue.
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