Characterization of a cell death-inhibiting gene identified by expression cloning
| Project/Area Number |
22710225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Research Collaborator |
ICHIKAWA Shinichi 新潟薬科大学, 応用生命科学部, 教授 (10223083)
NAKAZATO Yusuke 新潟薬科大学, 応用生命科学部, 卒業生
KOIKE Akane 新潟薬科大学, 応用生命科学部, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 細胞死 / トランスジェニックマウス / 活性酸素 |
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| Research Abstract |
Oxidative stress induces cell death, leading to various diseases. We have previously identified cDNAs that inhibit cell death induced by reactive oxygen species(ROS). In this study, we focused on one of the isolated cDNAs and characterized. First, expression and phosphorylation of some factors altered in the cells overexpressing this gene. Next, we observed that transgenic mice overexpressing this gene developed cataract.
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Report
(3 results)
Research Products
(13 results)
