| Project/Area Number |
22710228
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUTAMURA Yushi 独立行政法人理化学研究所, 化学情報・化合物創製チーム, 特別研究員 (70525857)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞形態変化 / ハイコンテントスクリーニング / ケミカルバイオロジー / モルフォローム / 微生物代謝産物 |
|---|
| Research Abstract |
To discover small drug like molecules, we have constructed the encyclopedia of cellular morphology, consisting of the cell-shape changes induced by various compounds. Particularly, we have developed high-content image analysis method to examine the effect of～ 100 routinely used chemicals on the cell morphology accompanied by statistical characterization of the obtained phenotypic data. We demonstrated the cell morphology-based profiling system not only reproduces "drug-target-phenotype" relationships for a series of drugs with known targets but also raises the possibility to clear the way to discovery of unique drug candidates.
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