Mechanism of dipeptide synthesis mediated by prolyl aminopeptidase
| Project/Area Number |
22710231
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Seikei University (2011)
岡山県農林水産総合センター生物科学研究所 (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | プロリルアミノペプチダーゼ / プロリン / ジペプチド / ジケトピペラジン / プロリルヒドロキシプロリン / アミノリシス / 放線菌 / 合成 / 遺伝子工学 |
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| Research Abstract |
Protease hydrolyze protein and release corresponding peptides. It is known that protease also exert synthetic reaction of peptide. Especially, Ser/Cys substituted protease shows increased synthetic activity. In this study, we revealed that Ser/Cys modified prolyl aminopeptidase also exert increased synthetic activity of proline containing dipeptides. Furthermore we established the enzymatic synthetic method of prolyl hydroxylproline which has attracted attention to prevent locomotive syndrome.
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Report
(3 results)
Research Products
(5 results)
