| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Many investigations into Alzheimer’s disease reveal the relatively early and substantial loss of cholinergic neurons, followed neurodegenerative abnormalities, as well as the severe impairment in cognition and memory. This study aimed the generation and assessment of animal model of Alzheimer’s disease in mice with memory deficiency and the examination about the effect of the drugs and neurodegenerative abnormalities along the cholinergic deficiency on memory impairment of the model. This study exhibited that the mouse with cholinergic ablation in basal forebrain might be a reliable animal model of Alzheimer’s disease and that there was the efficient drug for the memory recovery in the model mouse.
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